TY - JOUR
T1 - Effect of an H-2 antagonist on gallbladder contraction
AU - Gadacz, Thomas R.
N1 - Funding Information:
’ Supported by the Medical Research Service of the Veterans Administration.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1978/10
Y1 - 1978/10
N2 - Cimetidine, an H-2 blocker, is a potent inhibitor of stimulated acid secretion. Its effects on other tissues have not been completely described. Using strips of guinea pig gallbladder, the effect of cimetidine on histamine-stimulated muscle contraction was tested. Doses of 1.6 × 10-6, 4.05 × 10-6, and 8.1 × 10-6 M histamine acid phosphate produced graded increases of muscle contraction. When these doses were given in combination with 5 × 10-6 and 5 × 10-5 M cimetidine, there was a significant increase in muscle contraction. However, when 4.9 × 10-7 M diphenhydramine hydrochloride, an H-1 receptor inhibitor, was given in combination with histamine, muscle contraction was significantly inhibited. From these data it is concluded that the effects of histamine on gallbladder muscle in vitro are mediated through the H-1 receptor site; however, the H-2 receptor is present and is an inhibitor of muscle contraction.
AB - Cimetidine, an H-2 blocker, is a potent inhibitor of stimulated acid secretion. Its effects on other tissues have not been completely described. Using strips of guinea pig gallbladder, the effect of cimetidine on histamine-stimulated muscle contraction was tested. Doses of 1.6 × 10-6, 4.05 × 10-6, and 8.1 × 10-6 M histamine acid phosphate produced graded increases of muscle contraction. When these doses were given in combination with 5 × 10-6 and 5 × 10-5 M cimetidine, there was a significant increase in muscle contraction. However, when 4.9 × 10-7 M diphenhydramine hydrochloride, an H-1 receptor inhibitor, was given in combination with histamine, muscle contraction was significantly inhibited. From these data it is concluded that the effects of histamine on gallbladder muscle in vitro are mediated through the H-1 receptor site; however, the H-2 receptor is present and is an inhibitor of muscle contraction.
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U2 - 10.1016/0022-4804(78)90128-2
DO - 10.1016/0022-4804(78)90128-2
M3 - Article
C2 - 30862
AN - SCOPUS:0018216177
SN - 0022-4804
VL - 25
SP - 334
EP - 341
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 4
ER -