Effect of allopurinol on the survival of hyperemic island skin flaps

Michael J. Im, Wen Hui Shen, Chun J. Pak, Paul Manson, Gregory B. Bulkley, John E. Hoopes

Research output: Contribution to journalArticle

Abstract

Allopurinol was investigated in 3 x 6 cm congested island skin flaps in rats. Eight hours of venous occlusion produced total flap necrosis. Pretreatmetu with systemic allopurinol. an inhibitor of xanthine oxidase, enhanced the survival rate of hyperemic skin flaps. Xanthine oxidase activities were demonstrated in skin, and these enzyme activities were noted to increase in skin flaps during ischemia and reperfusion. Much of this increase in enzyme activity was prevented by allopurinol treatment. The xanthine oxidase system appears to be one of the sources of the superoxide radical, which may be involved in ischemic and reperfusion injury in skin.

Original languageEnglish (US)
Pages (from-to)276-278
Number of pages3
JournalPlastic and Reconstructive Surgery
Volume73
Issue number2
StatePublished - 1984

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Surgical Flaps
Allopurinol
Xanthine Oxidase
Skin
Enzymes
Reperfusion Injury
Superoxides
Reperfusion
Necrosis
Ischemia

ASJC Scopus subject areas

  • Surgery

Cite this

Im, M. J., Shen, W. H., Pak, C. J., Manson, P., Bulkley, G. B., & Hoopes, J. E. (1984). Effect of allopurinol on the survival of hyperemic island skin flaps. Plastic and Reconstructive Surgery, 73(2), 276-278.

Effect of allopurinol on the survival of hyperemic island skin flaps. / Im, Michael J.; Shen, Wen Hui; Pak, Chun J.; Manson, Paul; Bulkley, Gregory B.; Hoopes, John E.

In: Plastic and Reconstructive Surgery, Vol. 73, No. 2, 1984, p. 276-278.

Research output: Contribution to journalArticle

Im, MJ, Shen, WH, Pak, CJ, Manson, P, Bulkley, GB & Hoopes, JE 1984, 'Effect of allopurinol on the survival of hyperemic island skin flaps', Plastic and Reconstructive Surgery, vol. 73, no. 2, pp. 276-278.
Im, Michael J. ; Shen, Wen Hui ; Pak, Chun J. ; Manson, Paul ; Bulkley, Gregory B. ; Hoopes, John E. / Effect of allopurinol on the survival of hyperemic island skin flaps. In: Plastic and Reconstructive Surgery. 1984 ; Vol. 73, No. 2. pp. 276-278.
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