TY - JOUR
T1 - Effect of airborne particulate matter of 2.5 Μm or less on preterm birth
T2 - A national birth cohort study in China
AU - Li, Qin
AU - Wang, Yuan yuan
AU - Guo, Yuming
AU - Zhou, Hong
AU - Wang, Xiaobin
AU - Wang, Qiaomei
AU - Shen, Haiping
AU - Zhang, Yiping
AU - Yan, Donghai
AU - Zhang, Ya
AU - Zhang, Hongguang
AU - Li, Shanshan
AU - Chen, Gongbo
AU - Lin, Lizi
AU - Zhao, Jun
AU - He, Yuan
AU - Yang, Ying
AU - Xu, Jihong
AU - Wang, Yan
AU - Peng, Zuoqi
AU - Wang, Hai Jun
AU - Ma, Xu
N1 - Funding Information:
QL and HJW were supported by the National Natural Science Foundation of China ( 81573170 ) and Beijing Natural Science Foundation ( 7162106 ), YYW and XM were supported by the National Key Research and Development Program (No. 2016YFC1000300 , No. 2016YFC1000307 ). YG was supported by an Australian National Health and Medical Research Council Career Development Fellowship ( APP1107107 ). SL was supported by the Early Career Fellowship of the Australian National Health and Medical Research Council ( APP1109193 ) and Seed Funding from the National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE)–Centre for Air quality and health Research and evaluation (CAR) ( APP1030259 ). We thank health professionals in 30 provinces across China for their great efforts in the NFPHEP project.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/12
Y1 - 2018/12
N2 - Background: Most evidences regarding ambient PM2.5 or PM10 (particulate matter of median aerodynamic diameter ≤2.5 μm or ≤10 μm) and preterm birth (PTB) come from western countries which has relatively low PM pollution exposure, and the results are still inconsistent. This study aims to examine whether exposure to high concentrations of PM2.5 or PM10 was associated with PTB (<37 weeks) and near term birth (37–38 weeks). Method: We established a birth cohort with 1,280,524 singleton pregnancies who delivered from Dec 1st, 2013 to Nov 30th, 2014 and matched their home address to PM2.5 and PM10 concentrations which were predicted with machine learning methods based satellite remote sensing, meteorological and land use information. Cox proportional hazard regression models were used to analyze the associations between PTB and exposure of PM2.5 or PM10, after controlling for individual level covariates. Results: Exposure to PM2.5 or PM10 during pregnancy increases the risk of PTB and near term birth [e.g., Hazard ratios: 1.09 (95% CI: 1.09, 1.10), 1.08 (95% CI: 1.07, 1.08), 1.01 (95% CI: 1.01, 1.02), and 1.09 (95% CI: 1.08, 1.10) for each 10 μg/m3 increase in PM2.5 for the 1st, 2nd, 3rd trimester and over the entire pregnancy, respectively]. The effects appeared to be stronger among women who come from rural areas, worked as farmers, were overweight before conception, whose mate was smoking during pregnancy, and conceived in autumn. Conclusion: This study provides clear evidence that exposure to PM2.5 or PM10 during pregnancy increases the risk of PTB and near term birth. Public policies regarding improvement of air quality would produce great health benefit by reducing the burden of preterm birth.
AB - Background: Most evidences regarding ambient PM2.5 or PM10 (particulate matter of median aerodynamic diameter ≤2.5 μm or ≤10 μm) and preterm birth (PTB) come from western countries which has relatively low PM pollution exposure, and the results are still inconsistent. This study aims to examine whether exposure to high concentrations of PM2.5 or PM10 was associated with PTB (<37 weeks) and near term birth (37–38 weeks). Method: We established a birth cohort with 1,280,524 singleton pregnancies who delivered from Dec 1st, 2013 to Nov 30th, 2014 and matched their home address to PM2.5 and PM10 concentrations which were predicted with machine learning methods based satellite remote sensing, meteorological and land use information. Cox proportional hazard regression models were used to analyze the associations between PTB and exposure of PM2.5 or PM10, after controlling for individual level covariates. Results: Exposure to PM2.5 or PM10 during pregnancy increases the risk of PTB and near term birth [e.g., Hazard ratios: 1.09 (95% CI: 1.09, 1.10), 1.08 (95% CI: 1.07, 1.08), 1.01 (95% CI: 1.01, 1.02), and 1.09 (95% CI: 1.08, 1.10) for each 10 μg/m3 increase in PM2.5 for the 1st, 2nd, 3rd trimester and over the entire pregnancy, respectively]. The effects appeared to be stronger among women who come from rural areas, worked as farmers, were overweight before conception, whose mate was smoking during pregnancy, and conceived in autumn. Conclusion: This study provides clear evidence that exposure to PM2.5 or PM10 during pregnancy increases the risk of PTB and near term birth. Public policies regarding improvement of air quality would produce great health benefit by reducing the burden of preterm birth.
KW - Birth cohort
KW - Preterm birth
KW - Satellite-based PM and PM predictions
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U2 - 10.1016/j.envint.2018.10.025
DO - 10.1016/j.envint.2018.10.025
M3 - Article
C2 - 30352698
AN - SCOPUS:85055132617
SN - 0160-4120
SP - 1128
EP - 1136
JO - Environment international
JF - Environment international
ER -