@article{2997b6f005e64bd0828f14087b827b7f,
title = "Effect of age on the immunogenicity of yeast recombinant hepatitis b vaccines containing surface antigen (s) or pres2+s antigens",
abstract = "A single-blind, multicenter, phase II trial of yeast recombinant hepatitis B virus (HBV) vaccines containing surface antigen (S) alone or with PreS2 (PreS2+S) was conducted in 282 healthy HBV-seronegative adults aged 20-59 years. Each volunteer was randomly assigned to receive HBV vaccine containing 10 μg of S or one of three doses of PreS2 plus S: 2 + 10 μg, 4 + 20 μg, or 8 + 40 μg. The level of antibody to HBV surface antigen reached depended on the dose of S, not PreS2, received. In each vaccine group, volunteers 20-39 years old had higher titers of anti-PreS2 and antibody to S than those 40-59 years old. The age-related effect on immune response to HBV vaccination suggests that adults should beimmunized against hepatitis Bat as early an age as possible and that older persons may need a higher dose or booster immunizations to achieve durable immunity.",
author = "Clements, {Mary Lou} and Emil Miskovsky and Morton Davidson and Thomas Cupps and Newton Kumwenda and Sandman, {Laurie A.} and David West and Theresa Hesley and Virginia Ioll and William Miller and Gary Calandra and Saul Krugman",
note = "Funding Information: Received 12 January 1994; revised 13 April 1994. The study protocol adhered to guidelines of the US Department ofHealth and Human Services and was approved by the institutional review boards at Johns Hopkins University Medical Institutions. Georgetown University Hospital. and University Hospital of New York University Medical Center. Signed informed consent was obtained from all volunteers. Some authors are stockholders in Merck (D.W.•T.H .• V.I.. W.M.. a.c.). Financial support: Merck Research Laboratories and Fogarty Center. National Institutes of Health. Reprints or correspondence: Dr. Mary Lou Clements. Johns Hopkins University. Center for Immunization Research. 624 N. Broadway. Hampton House 225. Baltimore. MD 21205.",
year = "1994",
month = sep,
doi = "10.1093/infdis/170.3.510",
language = "English (US)",
volume = "170",
pages = "510--516",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",
}