Levels of plasma calcium, phosphorus, creatinine and 1,25-(OH)2-D were measured in healthy male Sprague-Dawley rats aged 6 months (mature) and 20-24 months (senescent). Plasma 1,25-(OH)2-D levels fell from 95 ± 50 pmol/l in the mature rats to 41 ± 10 pmol/l in the senescent rats (p <0.01). Despite a significant fall in plasma phosphate from 3.06 ± 0.37 mmol/l to 2.54 mmol/l (p <0.005) in the two groups, respectively, plasma calcium remained constant at about 2.4 mmol/l in both groups.
ASJC Scopus subject areas
- Geriatrics and Gerontology