Effect of Age and Renal Function on Survival After Left Ventricular Assist Device Implantation

Rahatullah Muslem, Kadir Caliskan, Sakir Akin, Yunus E. Yasar, Kavita Sharma, Nisha A. Gilotra, Isabella Kardys, Brian Houston, Glenn Whitman, Ryan J. Tedford, Dennis A. Hesselink, Ad J.J.C. Bogers, Olivier C. Manintveld, Stuart D. Russell

Research output: Contribution to journalArticlepeer-review

Abstract

Left ventricular assist devices (LVAD) are increasingly used, especially as destination therapy in in older patients. The aim of this study was to evaluate the effect of age on renal function and mortality in the first year after implantation. A retrospective multicenter cohort study was conducted, evaluating all LVAD patients implanted in the 2 participating centers (age ≥18 years). Patients were stratified according to the age groups <45, 45–54, 55–64, and ≥65 years old. Overall, 241 patients were included (mean age 52.4 ± 12.9 years, 76% males, 33% destination therapy). The mean estimated Glomerular Filtration Rate (eGFR) at 1 year was 85, 72, 69, and 49 mL/min per 1.73 m2 in the age groups <45(n = 65, 27%), 45–54(n = 52, 22%), 55–64(n = 87, 36%), and ≥65 years (n = 37, 15%) p <0.001)), respectively. Older age and lower eGFR at baseline (p <0.01) were independent predictors of worse renal function at 1 year. The 1-year survival post-implantation was 79%,84%, 68%, and 54% for those in the age group <45, 45–54, 55–64 and ≥65 years (Log-rank p = 0.003). Older age, lower eGFR and, INTERMACS class I were independent predictors of 1-year mortality. Furthermore, older patients (age > 60 years) with an impaired renal function (eGFR <55 mL/min per 1.73 m2) had a 5-fold increased hazard ratio for mortality during the first year after implantation (p <0.001). In conclusion, age >60 years is an independent predictor for an impaired renal function and mortality. Older age combined with reduced renal function pre-implantation had a cumulative adverse effect on survival in patients receiving a LVAD.

Original languageEnglish (US)
Pages (from-to)2221-2225
Number of pages5
JournalAmerican Journal of Cardiology
Volume120
Issue number12
DOIs
StatePublished - Dec 15 2017

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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