Effect of adult-onset deafness on the human central auditory system

Jean K. Moore, John K. Niparko, Michele R. Miller, Lucy M. Perazzo, Fred H. Linthicum

Research output: Contribution to journalArticle

Abstract

Degenerative change in the central auditory system was assessed in seven subjects with profound bilateral adult-onset deafness. The degree of transneuronal atrophy was determined by measuring cell size at three levels of the brain stem auditory pathway (anteroventral cochlear nucleus, medial superior olivary nucleus, and inferior colliculus). Within subjects, the relative degree of cell shrinkage was similar across all levels of the central pathway. Across subjects, the best neuronal preservation was seen in a case of viral labyrinthitis with 1 year of bilateral deafness and a near- normal population of cochlear ganglion cells. Reduction in cell size was greatest in cases of bacterial labyrinthitis or Scheibe degeneration with reduced populations of ganglion cells and longer periods of deafness. At the level of the cochlear nucleus, there was no consistent difference in cell size between the side stimulated by a functioning prosthetic device and the nonstimulated side.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalAnnals of Otology, Rhinology and Laryngology
Volume106
Issue number5
StatePublished - 1997

Fingerprint

Deafness
Labyrinthitis
Cell Size
Cochlear Nucleus
Ganglia
Auditory Pathways
Inferior Colliculi
Cochlea
Population
Brain Stem
Atrophy
Equipment and Supplies

Keywords

  • cochlear nucleus
  • heating loss
  • inferior colliculus
  • superior olive
  • transneuronal atrophy

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Moore, J. K., Niparko, J. K., Miller, M. R., Perazzo, L. M., & Linthicum, F. H. (1997). Effect of adult-onset deafness on the human central auditory system. Annals of Otology, Rhinology and Laryngology, 106(5), 385-390.

Effect of adult-onset deafness on the human central auditory system. / Moore, Jean K.; Niparko, John K.; Miller, Michele R.; Perazzo, Lucy M.; Linthicum, Fred H.

In: Annals of Otology, Rhinology and Laryngology, Vol. 106, No. 5, 1997, p. 385-390.

Research output: Contribution to journalArticle

Moore, JK, Niparko, JK, Miller, MR, Perazzo, LM & Linthicum, FH 1997, 'Effect of adult-onset deafness on the human central auditory system', Annals of Otology, Rhinology and Laryngology, vol. 106, no. 5, pp. 385-390.
Moore JK, Niparko JK, Miller MR, Perazzo LM, Linthicum FH. Effect of adult-onset deafness on the human central auditory system. Annals of Otology, Rhinology and Laryngology. 1997;106(5):385-390.
Moore, Jean K. ; Niparko, John K. ; Miller, Michele R. ; Perazzo, Lucy M. ; Linthicum, Fred H. / Effect of adult-onset deafness on the human central auditory system. In: Annals of Otology, Rhinology and Laryngology. 1997 ; Vol. 106, No. 5. pp. 385-390.
@article{157c55a6fc7a43caa91f3c88742f7159,
title = "Effect of adult-onset deafness on the human central auditory system",
abstract = "Degenerative change in the central auditory system was assessed in seven subjects with profound bilateral adult-onset deafness. The degree of transneuronal atrophy was determined by measuring cell size at three levels of the brain stem auditory pathway (anteroventral cochlear nucleus, medial superior olivary nucleus, and inferior colliculus). Within subjects, the relative degree of cell shrinkage was similar across all levels of the central pathway. Across subjects, the best neuronal preservation was seen in a case of viral labyrinthitis with 1 year of bilateral deafness and a near- normal population of cochlear ganglion cells. Reduction in cell size was greatest in cases of bacterial labyrinthitis or Scheibe degeneration with reduced populations of ganglion cells and longer periods of deafness. At the level of the cochlear nucleus, there was no consistent difference in cell size between the side stimulated by a functioning prosthetic device and the nonstimulated side.",
keywords = "cochlear nucleus, heating loss, inferior colliculus, superior olive, transneuronal atrophy",
author = "Moore, {Jean K.} and Niparko, {John K.} and Miller, {Michele R.} and Perazzo, {Lucy M.} and Linthicum, {Fred H.}",
year = "1997",
language = "English (US)",
volume = "106",
pages = "385--390",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Company",
number = "5",

}

TY - JOUR

T1 - Effect of adult-onset deafness on the human central auditory system

AU - Moore, Jean K.

AU - Niparko, John K.

AU - Miller, Michele R.

AU - Perazzo, Lucy M.

AU - Linthicum, Fred H.

PY - 1997

Y1 - 1997

N2 - Degenerative change in the central auditory system was assessed in seven subjects with profound bilateral adult-onset deafness. The degree of transneuronal atrophy was determined by measuring cell size at three levels of the brain stem auditory pathway (anteroventral cochlear nucleus, medial superior olivary nucleus, and inferior colliculus). Within subjects, the relative degree of cell shrinkage was similar across all levels of the central pathway. Across subjects, the best neuronal preservation was seen in a case of viral labyrinthitis with 1 year of bilateral deafness and a near- normal population of cochlear ganglion cells. Reduction in cell size was greatest in cases of bacterial labyrinthitis or Scheibe degeneration with reduced populations of ganglion cells and longer periods of deafness. At the level of the cochlear nucleus, there was no consistent difference in cell size between the side stimulated by a functioning prosthetic device and the nonstimulated side.

AB - Degenerative change in the central auditory system was assessed in seven subjects with profound bilateral adult-onset deafness. The degree of transneuronal atrophy was determined by measuring cell size at three levels of the brain stem auditory pathway (anteroventral cochlear nucleus, medial superior olivary nucleus, and inferior colliculus). Within subjects, the relative degree of cell shrinkage was similar across all levels of the central pathway. Across subjects, the best neuronal preservation was seen in a case of viral labyrinthitis with 1 year of bilateral deafness and a near- normal population of cochlear ganglion cells. Reduction in cell size was greatest in cases of bacterial labyrinthitis or Scheibe degeneration with reduced populations of ganglion cells and longer periods of deafness. At the level of the cochlear nucleus, there was no consistent difference in cell size between the side stimulated by a functioning prosthetic device and the nonstimulated side.

KW - cochlear nucleus

KW - heating loss

KW - inferior colliculus

KW - superior olive

KW - transneuronal atrophy

UR - http://www.scopus.com/inward/record.url?scp=0030944617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030944617&partnerID=8YFLogxK

M3 - Article

C2 - 9153102

AN - SCOPUS:0030944617

VL - 106

SP - 385

EP - 390

JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

IS - 5

ER -