Effect of adult-onset deafness on the human central auditory system

Jean K. Moore, John K. Niparko, Michele R. Miller, Lucy M. Perazzo, Fred H. Linthicum

Research output: Contribution to journalArticle

Abstract

Degenerative change in the central auditory system was assessed in seven subjects with profound bilateral adult-onset deafness. The degree of transneuronal atrophy was determined by measuring cell size at three levels of the brain stem auditory pathway (anteroventral cochlear nucleus, medial superior olivary nucleus, and inferior colliculus). Within subjects, the relative degree of cell shrinkage was similar across all levels of the central pathway. Across subjects, the best neuronal preservation was seen in a case of viral labyrinthitis with 1 year of bilateral deafness and a near- normal population of cochlear ganglion cells. Reduction in cell size was greatest in cases of bacterial labyrinthitis or Scheibe degeneration with reduced populations of ganglion cells and longer periods of deafness. At the level of the cochlear nucleus, there was no consistent difference in cell size between the side stimulated by a functioning prosthetic device and the nonstimulated side.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalAnnals of Otology, Rhinology and Laryngology
Volume106
Issue number5
StatePublished - 1997

Keywords

  • cochlear nucleus
  • heating loss
  • inferior colliculus
  • superior olive
  • transneuronal atrophy

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Moore, J. K., Niparko, J. K., Miller, M. R., Perazzo, L. M., & Linthicum, F. H. (1997). Effect of adult-onset deafness on the human central auditory system. Annals of Otology, Rhinology and Laryngology, 106(5), 385-390.