Effect of adrenergic drugs on cerebral blood flow, metabolism, and evoked potentials after delayed cardiopulmonary resuscitation in dogs

Hendrik W. Gervais, Charles L. Schleien, Raymond C. Koehler, Ivor D. Berkowitz, D. Hal Shaffner, Richard J. Traystman

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Epinephrine administration during cardiopulmonary resuscitation increases cerebral blood flow by increasing arterial pressure. We tested whether potential β-adrenergic effects of epinephrine directly influence cerebral blood flow and oxygen consumption independently of raising perfusion pressure. Methods: Four groups of seven anesthetized dogs were subjected to 8 minutes of fibrillatory arrest followed by 6 minutes of chest compression, ventricular defibrillation, and 4 hours of spontaneous circulation. Cerebral perfusion pressure was increased to approximately equivalent ranges during resuscitation by either 1) epinephrine infusion, 2) epinephrine infusion after pretreatment with the lipophylic β-adrenergic antagonist pindolol, 3) infusion of the α-adrenergic agonist phenylephrine, or 4) descending aortic balloon inflation without pressor agents. Results: We found no difference in cerebral blood flow, oxygen extraction, or oxygen consumption during chest compression among groups. After ventricular defibrillation, depressed levels of cerebral blood flow, cerebral oxygen consumption, and somatosensory evoked potential amplitude were not different among groups. Conclusions: We detected no evidence that after 8 minutes of complete ischemia, epinephrine administration during resuscitation substantially influences cerebral blood flow or cerebral oxygen consumption independent of its action of raising arterial pressure or that epinephrine has a negative impact on immediate metabolic or electrophysiological recovery attributable to its β-adrenergic activity.

Original languageEnglish (US)
Pages (from-to)1554-1561
Number of pages8
JournalStroke
Volume22
Issue number12
DOIs
StatePublished - Dec 1991

Keywords

  • Cerebral blood flow
  • Dogs
  • Epinephrine
  • Resuscitation

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Fingerprint Dive into the research topics of 'Effect of adrenergic drugs on cerebral blood flow, metabolism, and evoked potentials after delayed cardiopulmonary resuscitation in dogs'. Together they form a unique fingerprint.

  • Cite this