TY - JOUR
T1 - Effect of administering recombinant erythropoietin to women with postpartum anemia
T2 - A meta-analysis
AU - Kotto-Kome, Anne C.
AU - Calhoun, Darlene A.
AU - Montenegro, Raul
AU - Sosa, Roberto
AU - Maldonado, Luis
AU - Christensen, Robert D.
N1 - Funding Information:
R.D.C was supported by Grants HL-61798, HD-69990 and HD-42308, and D.A.C. was supported by Grants HD-01180 and HD-42326 from the National Institutes of Health.
PY - 2004/1
Y1 - 2004/1
N2 - Objectives: Recombinant erythropoietin (rEpo) has been administered to women with postpartum anemia in an attempt to accelerate their increase in hemoglobin concentration and reduce postpartum transfusions. However, it is not clear whether an approach can be supported by evidence and should be generally recommended. Study Design and Methods: Medical and scientific literature from January 1990 to December 2002 was searched and studies that reported the administration of rEpo to women with postpartum anemia were evaluated. Results: Eight evaluated studies reported an aggregate of 480 women; 300 rEpo recipients and 180 controls. Significant diversity in design was observed in rEpo dose, route of rEpo administration, iron supplementation, and baseline hemoglobin. No significant safety concerns were reported. In all five studies where it was reported, 4 to 7 days after beginning treatment, greater increases in hemoglobin concentration were observed among the rEpo recipients than among the controls. However, heterogeneity of results (Q-test statistic, p<0.01) indicated that it was not appropriate to apply summary statistics. The effect of rEpo on postpartum transfusion rate was not measurable by summary statistics because of the limited number of transfusions given (no transfusions among the 300 rEpo recipients vs two transfusions among the 180 controls. Conclusion: Administration of rEpo to women with postpartum anemia appears to be safe, and is associated with a trend toward a faster increase in hemoglobin concentration. However, its efficacy in terms of diminishing postpartum transfusions is unproven.
AB - Objectives: Recombinant erythropoietin (rEpo) has been administered to women with postpartum anemia in an attempt to accelerate their increase in hemoglobin concentration and reduce postpartum transfusions. However, it is not clear whether an approach can be supported by evidence and should be generally recommended. Study Design and Methods: Medical and scientific literature from January 1990 to December 2002 was searched and studies that reported the administration of rEpo to women with postpartum anemia were evaluated. Results: Eight evaluated studies reported an aggregate of 480 women; 300 rEpo recipients and 180 controls. Significant diversity in design was observed in rEpo dose, route of rEpo administration, iron supplementation, and baseline hemoglobin. No significant safety concerns were reported. In all five studies where it was reported, 4 to 7 days after beginning treatment, greater increases in hemoglobin concentration were observed among the rEpo recipients than among the controls. However, heterogeneity of results (Q-test statistic, p<0.01) indicated that it was not appropriate to apply summary statistics. The effect of rEpo on postpartum transfusion rate was not measurable by summary statistics because of the limited number of transfusions given (no transfusions among the 300 rEpo recipients vs two transfusions among the 180 controls. Conclusion: Administration of rEpo to women with postpartum anemia appears to be safe, and is associated with a trend toward a faster increase in hemoglobin concentration. However, its efficacy in terms of diminishing postpartum transfusions is unproven.
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U2 - 10.1038/sj.jp.7211017
DO - 10.1038/sj.jp.7211017
M3 - Article
C2 - 14726931
AN - SCOPUS:0742271683
SN - 0743-8346
VL - 24
SP - 11
EP - 15
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 1
ER -