Effect of acidosis on heart camp-dependent protein kinase

Liliana E. Chiappe De Mon, Gladys E. Chiappe De Cingolani, H. E. Cingolani

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of acidosis on cAMP-dependent protein kinase activity in perfused hearts from normal and reserpinized rats has been investigated. The results were compared to the effect of acidosis on myocardial contractility under the same conditions. The results showed that acidosis increases the cAMP-dependent protein kinase activity in normal hearts. This increase was abolished when the hearts were depleted of norepinephrine by previous treatment with reserpine. As regards myocardial contractility, there was a similar decrease by acidosis either in normal hearts with increased cAMP-dependent protein kinase activity or in reserpinized hearts in which the increase in protein kinase activity was prevented. Two alternative hypotheses are suggested : (1) a dissociation between contractility and cAMP levels, or (2) a "blockade" by acidosis of the mechanical effect of increasing cAMP-dependent protein kinase activity.

Original languageEnglish (US)
Pages (from-to)277-287
Number of pages11
JournalArchives of Physiology and Biochemistry
Volume86
Issue number2
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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