Effect of a Recombinant CD4-IgG on In Vitro T Helper Cell Function: Data from a Phase I/II Study of Patients with AIDS

Mario Clerici, Robert Yarchoan, Stephen Blatt, Craig W. Hendrix, Arthur J. Ammann, Samuel Broder, Gene M. Shearer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Ten patients with AIDS were enrolled in a phase I/II protocol of recombinant CD4-IgG (rCD4-IgG) treatment. Patients’ peripheral blood leukocytes (PBL) were tested before, during, and after therapy with rCD4-IgG for T helper (TH) cell function assessed by antigen- and mitogen- stimulated proliferation and interleukin-2 production in response to influenza A virus, allogeneic PBL (alloantigens), and phytohemagglutinin. Although clinical benefit was not evident, rCD4-lgG treatment was associated with rapid and potent improved TH cell function for two of three stimuli tested in 90% of the patients. These data are complemented by an in vitro experimental model that demonstrates the opposing immunologic effects ofrgp120 and rCD4-lgG on TH cell function of PBL from uninfected individuals. Thus, restoration of TH cell function by rCD4-lgG in the absence ofincreased CD4 cell counts could be due to removal ofan immunosuppressive factor, possibly gp120. These findings suggest that rCD4-lgG can induce partial restoration of immune function in AIDS patients, even in the absence of apparent short-term clinical benefit.

Original languageEnglish (US)
Pages (from-to)1012-1016
Number of pages5
JournalJournal of Infectious Diseases
Volume168
Issue number4
DOIs
StatePublished - Oct 1993
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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