TY - JOUR
T1 - Effect of a high-protein diet on kidney function in healthy adults
T2 - Results from the omniheart trial
AU - Juraschek, Stephen P.
AU - Appel, Lawrence J.
AU - Anderson, Cheryl A.M.
AU - Miller, Edgar R.
N1 - Funding Information:
Support: Mr Juraschek is supported by National Institutes of Health/National Heart, Lung and Blood Institute Cardiovascular Epidemiology Training Grant T32HL007024 and Dr Miller is supported by grant R01HL095448.
PY - 2013/4
Y1 - 2013/4
N2 - Background: Consumption of a diet high in protein can cause glomerular hyperfiltration, a potentially maladaptive response, which may accelerate the progression of kidney disease. Study Design: An ancillary study of the OmniHeart trial, a randomized 3-period crossover feeding trial testing the effects of partial replacement of carbohydrate with protein on kidney function. Setting & Participants: Healthy adults (N=164) with prehypertension or stage 1 hypertension at a community-based research clinic with a metabolic kitchen. Intervention: Participants were fed each of 3 diets for 6 weeks. Feeding periods were separated by a 2- to 4-week washout period. Weight was held constant on each diet. The 3 diets emphasized carbohydrate, protein, or unsaturated fat; dietary protein was either 15% (carbohydrate and unsaturated fat diets) or 25% (protein diet) of energy intake. Outcomes: Fasting serum creatinine, cystatin C, and β2-microglobulin levels, estimated glomerular filtration rate (eGFR). Measurements: Serum creatinine, cystatin C, and β2-microglobulin collected at the end of each feeding period. Results: Baseline cystatin C-based eGFR was 92.0 ± 16.3 (SD) mL/min/1.73 m2. Compared with the carbohydrate and unsaturated fat diets, the protein diet increased cystatin C-based eGFR by ∼4 mL/min/1.73 m2 (P < 0.001). The effects of the protein diet on kidney function were independent of changes in blood pressure. There was no significant difference between the carbohydrate and unsaturated fat diets. Limitations: Participants did not have kidney disease at baseline. Conclusions: A healthy diet rich in protein increased eGFR. Whether long-term consumption of a high-protein diet leads to kidney disease is uncertain.
AB - Background: Consumption of a diet high in protein can cause glomerular hyperfiltration, a potentially maladaptive response, which may accelerate the progression of kidney disease. Study Design: An ancillary study of the OmniHeart trial, a randomized 3-period crossover feeding trial testing the effects of partial replacement of carbohydrate with protein on kidney function. Setting & Participants: Healthy adults (N=164) with prehypertension or stage 1 hypertension at a community-based research clinic with a metabolic kitchen. Intervention: Participants were fed each of 3 diets for 6 weeks. Feeding periods were separated by a 2- to 4-week washout period. Weight was held constant on each diet. The 3 diets emphasized carbohydrate, protein, or unsaturated fat; dietary protein was either 15% (carbohydrate and unsaturated fat diets) or 25% (protein diet) of energy intake. Outcomes: Fasting serum creatinine, cystatin C, and β2-microglobulin levels, estimated glomerular filtration rate (eGFR). Measurements: Serum creatinine, cystatin C, and β2-microglobulin collected at the end of each feeding period. Results: Baseline cystatin C-based eGFR was 92.0 ± 16.3 (SD) mL/min/1.73 m2. Compared with the carbohydrate and unsaturated fat diets, the protein diet increased cystatin C-based eGFR by ∼4 mL/min/1.73 m2 (P < 0.001). The effects of the protein diet on kidney function were independent of changes in blood pressure. There was no significant difference between the carbohydrate and unsaturated fat diets. Limitations: Participants did not have kidney disease at baseline. Conclusions: A healthy diet rich in protein increased eGFR. Whether long-term consumption of a high-protein diet leads to kidney disease is uncertain.
KW - Diet
KW - cystatin C
KW - glomerular filtration rate
KW - macronutrients
KW - randomized controlled trial
KW - β-microglobulin
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U2 - 10.1053/j.ajkd.2012.10.017
DO - 10.1053/j.ajkd.2012.10.017
M3 - Article
C2 - 23219108
AN - SCOPUS:84875210768
SN - 0272-6386
VL - 61
SP - 547
EP - 554
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 4
ER -