Effect of 7-nitroindazole on body temperature and methamphetamine- induced dopamine toxicity

Brian T. Callahan, George A. Ricaurte

Research output: Contribution to journalArticlepeer-review

Abstract

THE present study was undertaken to examine the role of temperature on the ability of 7-nitroindazole (7-NI) to prevent methamphetamine-induced dopamine (DA) neurotoxicity. Male Swiss-Webster mice received methamphetamine alone or in combination with 7-NI at either room temperature (20 ± 1°C) or at 28 ± 1°C. At 20 ± °C, 7-NI produced hypothermic effects and afforded total protection against methamphetamine-induced DA depletions in the striatum. At 28 ± 1°C, 7-NI produced minimal effects on body temperature and failed to prevent methamphetamine-induced DA reductions. These findings indicate that the neuroprotection afforded by 7-NI is likely related to its ability to produce hypothermia because agents that produce hypothermia and/or prevent hyperthermia are known to attenuate methamphetamine-induced neurotoxicity.

Original languageEnglish (US)
Pages (from-to)2691-2695
Number of pages5
JournalNeuroreport
Volume9
Issue number12
DOIs
StatePublished - Aug 24 1998

Keywords

  • 7- Nitroindazole
  • Dopamine
  • Methamphetamine
  • Neurotoxicity
  • Nitric oxide
  • Temperature

ASJC Scopus subject areas

  • Neuroscience(all)

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