Effect of 3-methylcholanthrene on immune response and thymus weight of Buffalo strain rats

David A. Silverman, Noel R. Rose

Research output: Contribution to journalArticle

Abstract

Buffalo (BUF) strain rats developed autoimmune thyroiditis spontaneously and the incidence was increased by administration of 3-methylcholanthrene (MCA). MCA did not alter the response of BUF rats to sheep red blood cells in terms of antibody titers or plaque-forming cells. However, hypersensitivity to BCG was reduced and thymus weight decreased significantly.

Original languageEnglish (US)
Pages (from-to)1721-1724
Number of pages4
JournalJournal of the National Cancer Institute
Volume53
Issue number6
DOIs
StatePublished - Dec 1974

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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