TY - JOUR
T1 - Effect of β-funaltrexamine on retention of passive-avoidance conditioning
AU - Gallagher, M.
N1 - Funding Information:
l Supported by NIMH Grant MH 35554 and a Research Scientist Development Award KO2 MH00406 (NIMH) to M.G. The naloxone hydrochloride was provided by Endo Laboratories, Inc., Garden City, NY. The/3-FNA was generously provided by Dr. David Leander, Eli Lilly Laboratories, IN. Dr. Leander's consultation and review of this manuscript is also gratefully acknowledged. Send correspondence and requests for reprints to Dr. Gallagher.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1985/11
Y1 - 1985/11
N2 - Rats received administration of an opiate antagonist immediately following single-trial passive-avoidance training. Retention of passive-avoidance conditioning was assessed 1 week after training. Compared to noninjected and vehicle-injected control groups, post-training naloxone (2.0 mg/kg) administration significantly increased retention. A comparable facilitation of retention was also observed when animals received post-training administration of β-funaltrexamine (40 mg/kg). These data provide additional support for mu opiate receptor activity in the regulation of memory processes.
AB - Rats received administration of an opiate antagonist immediately following single-trial passive-avoidance training. Retention of passive-avoidance conditioning was assessed 1 week after training. Compared to noninjected and vehicle-injected control groups, post-training naloxone (2.0 mg/kg) administration significantly increased retention. A comparable facilitation of retention was also observed when animals received post-training administration of β-funaltrexamine (40 mg/kg). These data provide additional support for mu opiate receptor activity in the regulation of memory processes.
UR - http://www.scopus.com/inward/record.url?scp=0022339796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022339796&partnerID=8YFLogxK
U2 - 10.1016/S0163-1047(85)90976-8
DO - 10.1016/S0163-1047(85)90976-8
M3 - Article
C2 - 3002317
AN - SCOPUS:0022339796
SN - 0163-1047
VL - 44
SP - 499
EP - 502
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 3
ER -