Effect of β-blockade on regional left ventricular function in patients with dilated cardiomyopathy

Takakazu Morozumi, Yoshio Ishida, Hideo Kusuoka, Hideyuki Sato, Masatsugu Hori, Takenobu Kamada, Tsunehiko Nishimura

Research output: Contribution to journalArticle

Abstract

It has been reported that β-blockade has beneficial effects on the cardiac function and prognosis of patients with congestive heart failure. However, the mechanism for these effects remained unclear. This study compared the use of an angiotensin-converting enzyme (ACE) inhibitor (enalapril, 2.5 to 5.0 mg/day, or delapril, 15 to 30 mg/day) alone with the effects of β-blockade therapy (metoprolol, 40 to 60 mg/day) coupled with an ACE inhibitor on global and regional left ventricular (LV) function in patients with dilated cardiomyopathy. In 12 patients with dilated cardiomyopathy, the global LV ejection fraction (EF), regional EF (rEF), and regional ejection time (rET) were determined by sector analysis of the radionuclide ventriculogram before and after therapy (duration 14±9 months). The coefficients of variation of rEF and rET were calculated as indexes of the heterogeneity of regional LV systolic wall motion. EF increased significantly from 20%±8% to 30%±8% (p

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
JournalJournal of Nuclear Cardiology
Volume2
Issue number3
DOIs
StatePublished - May 1995
Externally publishedYes

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Dilated Cardiomyopathy
Left Ventricular Function
Angiotensin-Converting Enzyme Inhibitors
Enalapril
Metoprolol
Radioisotopes
Stroke Volume
Heart Failure
Therapeutics

Keywords

  • β-blocker
  • congestive heart failure
  • regional wall motion
  • synchrony

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Effect of β-blockade on regional left ventricular function in patients with dilated cardiomyopathy. / Morozumi, Takakazu; Ishida, Yoshio; Kusuoka, Hideo; Sato, Hideyuki; Hori, Masatsugu; Kamada, Takenobu; Nishimura, Tsunehiko.

In: Journal of Nuclear Cardiology, Vol. 2, No. 3, 05.1995, p. 231-237.

Research output: Contribution to journalArticle

Morozumi, T, Ishida, Y, Kusuoka, H, Sato, H, Hori, M, Kamada, T & Nishimura, T 1995, 'Effect of β-blockade on regional left ventricular function in patients with dilated cardiomyopathy', Journal of Nuclear Cardiology, vol. 2, no. 3, pp. 231-237. https://doi.org/10.1016/S1071-3581(05)80060-1
Morozumi, Takakazu ; Ishida, Yoshio ; Kusuoka, Hideo ; Sato, Hideyuki ; Hori, Masatsugu ; Kamada, Takenobu ; Nishimura, Tsunehiko. / Effect of β-blockade on regional left ventricular function in patients with dilated cardiomyopathy. In: Journal of Nuclear Cardiology. 1995 ; Vol. 2, No. 3. pp. 231-237.
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