EFECTOS DE LAS MODIFICACIONES ACIDO BASICAS SOBRE LA RESPUESTA CRONOTROPICA A LA NORADRENALINA

M. C. Camilion de Hurtado, O. A. Gende, H. E. Cingolani

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The effect of changes in pH produced by changing NaHCO2 at constant pCO2 and by changing pCO2 at constant NaHCO2 concentration was studied in the spontaneous beating rat atrium. Alkalosis produced either by changes in pCO2 or in NaHCO2 concentration increased basal heart rate shifting dose response curves to norepinephrine upwards. When these dose response curves were analysed for a horizontal shift, it was found that the necessary dose to produce a given effect was lesser in alkalosis than in acidosis. This shift was significant at the ED10 and at ED30 when the pCO2 was lowered and at ED30, ED50 and ED70 when the NaHCO2 concentration was increased. β adrenergic blockade did not prevent the rate increasing effect of alkalosis. The results suggest that there is a sensitizing effect to norepinephrine in alkalosis superimposed to a direct effect of pH upon heart rate.

Original languageEnglish (US)
Title of host publicationActa Physiologica Latino-Americana
Pages120-127
Number of pages8
Volume25
Edition2
StatePublished - 1975
Externally publishedYes

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Alkalosis
Norepinephrine
Heart Rate
Acidosis
Adrenergic Agents
basica

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

Cite this

Camilion de Hurtado, M. C., Gende, O. A., & Cingolani, H. E. (1975). EFECTOS DE LAS MODIFICACIONES ACIDO BASICAS SOBRE LA RESPUESTA CRONOTROPICA A LA NORADRENALINA. In Acta Physiologica Latino-Americana (2 ed., Vol. 25, pp. 120-127)

EFECTOS DE LAS MODIFICACIONES ACIDO BASICAS SOBRE LA RESPUESTA CRONOTROPICA A LA NORADRENALINA. / Camilion de Hurtado, M. C.; Gende, O. A.; Cingolani, H. E.

Acta Physiologica Latino-Americana. Vol. 25 2. ed. 1975. p. 120-127.

Research output: Chapter in Book/Report/Conference proceedingChapter

Camilion de Hurtado, MC, Gende, OA & Cingolani, HE 1975, EFECTOS DE LAS MODIFICACIONES ACIDO BASICAS SOBRE LA RESPUESTA CRONOTROPICA A LA NORADRENALINA. in Acta Physiologica Latino-Americana. 2 edn, vol. 25, pp. 120-127.
Camilion de Hurtado MC, Gende OA, Cingolani HE. EFECTOS DE LAS MODIFICACIONES ACIDO BASICAS SOBRE LA RESPUESTA CRONOTROPICA A LA NORADRENALINA. In Acta Physiologica Latino-Americana. 2 ed. Vol. 25. 1975. p. 120-127
Camilion de Hurtado, M. C. ; Gende, O. A. ; Cingolani, H. E. / EFECTOS DE LAS MODIFICACIONES ACIDO BASICAS SOBRE LA RESPUESTA CRONOTROPICA A LA NORADRENALINA. Acta Physiologica Latino-Americana. Vol. 25 2. ed. 1975. pp. 120-127
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