EEG-based detection of awakening from isoflurane anesthesia in rats

Jukka Kortelainen, Eero Väyrynen, Xiaofeng Jia, Tapio Seppänen, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In animal studies, reliable measures for depth of anesthesia are frequently required. Previous findings suggest that the continuous depth of anesthesia indices developed for humans might not be adequate for rats whose EEG changes during anesthesia represent more of quick transitions between discrete states. In this paper, the automatic EEG-based detection of awakening from anesthesia was studied in rats. An algorithm based on Bayesian Information Criterion (BIC) is proposed for the assessment of the switch-like change in the signal characteristics occurring just before the awakening. The method was tested with EEGs recorded from ten rats recovering from isoflurane anesthesia. The algorithm was shown to be able to detect the sudden change in the EEG related to the moment of awakening with a precision comparable to careful visual inspection. Our findings suggest that monitoring such signal changes may offer an interesting alternative to the application of continuous depth of anesthesia indices when avoiding the awakening of the animal during e.g. a clinical experiment.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages4279-4282
Number of pages4
DOIs
Publication statusPublished - 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Other

Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

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ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Kortelainen, J., Väyrynen, E., Jia, X., Seppänen, T., & Thakor, N. V. (2012). EEG-based detection of awakening from isoflurane anesthesia in rats. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 4279-4282). [6346912] https://doi.org/10.1109/EMBC.2012.6346912