Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia

Richard Anthony Edward Edden, Ashley D. Harris, Kevin Murphy, C. John Evans, Neeraj Saxena, Judith E. Hall, Damian M. Bailey, Richard G. Wise

Research output: Contribution to journalArticle

Abstract

Purpose: To demonstrate the application of Mescher-Garwood (MEGA) point-resolved spectroscopy sequence (PRESS) editing to the detection of lactate in the brain at 3T and to investigate changes in lactate concentration associated with inspiratory gas challenges. Materials and Methods: Edited lactate measurements were made in six healthy volunteers while the subjects breathed normoxic (21% O2), hypoxic (12% O2), and hyperoxic (40% O2) gas mixtures. Lactate concentration was quantified relative to the unsuppressed water signal from the same volume. Results: Lactate concentration was elevated in all subjects during hypoxia in a highly significant fashion (mean increase = 39%; P = 0.0003). There was no significant change seen in hyperoxia. Conclusion: MEGA-PRESS editing at 3T is sufficiently sensitive to detect lactate in the healthy brain with good signal-to-noise ratio (SNR), and can be used to investigate changes in cerebral metabolism arising during inspiratory gas challenges.

Original languageEnglish (US)
Pages (from-to)320-325
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume32
Issue number2
DOIs
StatePublished - Aug 2010

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Lactic Acid
Gases
Spectrum Analysis
Hyperoxia
Brain
Signal-To-Noise Ratio
Hypoxia
Healthy Volunteers
Water

Keywords

  • Hyperoxia
  • Hypoxia
  • Lactate
  • MEGA-PRESS
  • MRS

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia. / Edden, Richard Anthony Edward; Harris, Ashley D.; Murphy, Kevin; Evans, C. John; Saxena, Neeraj; Hall, Judith E.; Bailey, Damian M.; Wise, Richard G.

In: Journal of Magnetic Resonance Imaging, Vol. 32, No. 2, 08.2010, p. 320-325.

Research output: Contribution to journalArticle

Edden, RAE, Harris, AD, Murphy, K, Evans, CJ, Saxena, N, Hall, JE, Bailey, DM & Wise, RG 2010, 'Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia', Journal of Magnetic Resonance Imaging, vol. 32, no. 2, pp. 320-325. https://doi.org/10.1002/jmri.22233
Edden, Richard Anthony Edward ; Harris, Ashley D. ; Murphy, Kevin ; Evans, C. John ; Saxena, Neeraj ; Hall, Judith E. ; Bailey, Damian M. ; Wise, Richard G. / Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia. In: Journal of Magnetic Resonance Imaging. 2010 ; Vol. 32, No. 2. pp. 320-325.
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AU - Murphy, Kevin

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AU - Bailey, Damian M.

AU - Wise, Richard G.

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AB - Purpose: To demonstrate the application of Mescher-Garwood (MEGA) point-resolved spectroscopy sequence (PRESS) editing to the detection of lactate in the brain at 3T and to investigate changes in lactate concentration associated with inspiratory gas challenges. Materials and Methods: Edited lactate measurements were made in six healthy volunteers while the subjects breathed normoxic (21% O2), hypoxic (12% O2), and hyperoxic (40% O2) gas mixtures. Lactate concentration was quantified relative to the unsuppressed water signal from the same volume. Results: Lactate concentration was elevated in all subjects during hypoxia in a highly significant fashion (mean increase = 39%; P = 0.0003). There was no significant change seen in hyperoxia. Conclusion: MEGA-PRESS editing at 3T is sufficiently sensitive to detect lactate in the healthy brain with good signal-to-noise ratio (SNR), and can be used to investigate changes in cerebral metabolism arising during inspiratory gas challenges.

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