Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia

Richard A.E. Edden, Ashley D. Harris, Kevin Murphy, C. John Evans, Neeraj Saxena, Judith E. Hall, Damian M. Bailey, Richard G. Wise

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To demonstrate the application of Mescher-Garwood (MEGA) point-resolved spectroscopy sequence (PRESS) editing to the detection of lactate in the brain at 3T and to investigate changes in lactate concentration associated with inspiratory gas challenges. Materials and Methods: Edited lactate measurements were made in six healthy volunteers while the subjects breathed normoxic (21% O2), hypoxic (12% O2), and hyperoxic (40% O2) gas mixtures. Lactate concentration was quantified relative to the unsuppressed water signal from the same volume. Results: Lactate concentration was elevated in all subjects during hypoxia in a highly significant fashion (mean increase = 39%; P = 0.0003). There was no significant change seen in hyperoxia. Conclusion: MEGA-PRESS editing at 3T is sufficiently sensitive to detect lactate in the healthy brain with good signal-to-noise ratio (SNR), and can be used to investigate changes in cerebral metabolism arising during inspiratory gas challenges.

Original languageEnglish (US)
Pages (from-to)320-325
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume32
Issue number2
DOIs
StatePublished - Aug 2010

Keywords

  • Hyperoxia
  • Hypoxia
  • Lactate
  • MEGA-PRESS
  • MRS

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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