Ectopic activity generated by early after-depolarizations in ventricular tissue: A computer simulation study

Javier Saiz; Marta Monserrat; Jose M. Ferrero; Jose M. Ferrero; Nitish V. Thakor

Ectopic activity generated by early after-depolarizations in ventricular tissue: A computer simulation study

Javier Saiz, Marta Monserrat, Jose M. Ferrero, Jose M. Ferrero, Nitish V. Thakor

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A computer model of two partially coupled ventricular fibers was used to study conditions in which EADs generated in a zone of ventricular myocardium may propagate to other zones, inducing ectopic activity. The model consists of two one-dimensional arrays of cells coupled by a resistance R. EADs are induced in one of the segments while the other is kept under normal conditions. For values of R in the range from 38 Ωcm² to 50 Ωcm² the second EAD that appears in the EAD segment propagates to the normal segment as an ectopic beat. For R values out of this range the EAD only increases the action potential duration in some cells of the normal zone and ectopic activity in the normal cells is not observed.

Original language	English (US)
Pages (from-to)	601-604
Number of pages	4
Journal	Computers in cardiology
Volume	0
Issue number	0
State	Published - 1996

ASJC Scopus subject areas

Computer Science Applications
Cardiology and Cardiovascular Medicine

Cite this

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abstract = "A computer model of two partially coupled ventricular fibers was used to study conditions in which EADs generated in a zone of ventricular myocardium may propagate to other zones, inducing ectopic activity. The model consists of two one-dimensional arrays of cells coupled by a resistance R. EADs are induced in one of the segments while the other is kept under normal conditions. For values of R in the range from 38 Ωcm2 to 50 Ωcm2 the second EAD that appears in the EAD segment propagates to the normal segment as an ectopic beat. For R values out of this range the EAD only increases the action potential duration in some cells of the normal zone and ectopic activity in the normal cells is not observed.",

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AU - Thakor, Nitish V.

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N2 - A computer model of two partially coupled ventricular fibers was used to study conditions in which EADs generated in a zone of ventricular myocardium may propagate to other zones, inducing ectopic activity. The model consists of two one-dimensional arrays of cells coupled by a resistance R. EADs are induced in one of the segments while the other is kept under normal conditions. For values of R in the range from 38 Ωcm2 to 50 Ωcm2 the second EAD that appears in the EAD segment propagates to the normal segment as an ectopic beat. For R values out of this range the EAD only increases the action potential duration in some cells of the normal zone and ectopic activity in the normal cells is not observed.

AB - A computer model of two partially coupled ventricular fibers was used to study conditions in which EADs generated in a zone of ventricular myocardium may propagate to other zones, inducing ectopic activity. The model consists of two one-dimensional arrays of cells coupled by a resistance R. EADs are induced in one of the segments while the other is kept under normal conditions. For values of R in the range from 38 Ωcm2 to 50 Ωcm2 the second EAD that appears in the EAD segment propagates to the normal segment as an ectopic beat. For R values out of this range the EAD only increases the action potential duration in some cells of the normal zone and ectopic activity in the normal cells is not observed.

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Ectopic activity generated by early after-depolarizations in ventricular tissue: A computer simulation study

Abstract

ASJC Scopus subject areas

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