Ectopic activity generated by early after-depolarizations in ventricular tissue: A computer simulation study

Javier Saiz, Marta Monserrat, Jose M. Ferrero, Jose M. Ferrero, Nitish V. Thakor

Research output: Contribution to journalArticle


A computer model of two partially coupled ventricular fibers was used to study conditions in which EADs generated in a zone of ventricular myocardium may propagate to other zones, inducing ectopic activity. The model consists of two one-dimensional arrays of cells coupled by a resistance R. EADs are induced in one of the segments while the other is kept under normal conditions. For values of R in the range from 38 Ωcm2 to 50 Ωcm2 the second EAD that appears in the EAD segment propagates to the normal segment as an ectopic beat. For R values out of this range the EAD only increases the action potential duration in some cells of the normal zone and ectopic activity in the normal cells is not observed.

Original languageEnglish (US)
Pages (from-to)601-604
Number of pages4
JournalComputers in cardiology
Issue number0
StatePublished - Dec 1 1996


ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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