Abstract
Background: Since special efforts are necessary to vaccinate people living far from fixed vaccination posts, decision makers are interested in knowing the economic value of such efforts. Methods: Using our immunization geospatial information system platform and a measles compartment model, we quantified the health and economic value of a 2-dose measles immunization outreach strategy for children <24 months of age in Kenya who are geographically hard-to-reach (i.e., those living outside a specified catchment radius from fixed vaccination posts, which served as a proxy for access to services). Findings: When geographically hard-to-reach children were not vaccinated, there were 1427 total measles cases from 2016 to 2020, resulting in $9.5 million ($3.1–$18.1 million) in direct medical costs and productivity losses and 7504 (3338–12,903) disability-adjusted life years (DALYs). The outreach strategy cost $76 ($23–$142)/DALY averted (compared to no outreach) when 25% of geographically hard-to-reach children received MCV1, $122 ($40-$226)/DALY averted when 50% received MCV1, and $274 ($123-$478)/DALY averted when 100% received MCV1. Conclusion: Outreach vaccination among geographically hard-to-reach populations was highly cost-effective in a wide variety of scenarios, offering support for investment in an effective outreach vaccination strategy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2377-2386 |
| Number of pages | 10 |
| Journal | Vaccine |
| Volume | 37 |
| Issue number | 17 |
| DOIs | |
| State | Published - Apr 17 2019 |
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Keywords
- Economic
- Hard-to-reach populations
- Vaccination
ASJC Scopus subject areas
- Molecular Medicine
- Immunology and Microbiology(all)
- veterinary(all)
- Public Health, Environmental and Occupational Health
- Infectious Diseases
Cite this
Economic value of vaccinating geographically hard-to-reach populations with measles vaccine : A modeling application in Kenya. / Lee, Bruce; Brown, Shawn T.; Haidari, Leila A.; Clark, Samantha; Abimbola, Taiwo; Pallas, Sarah E.; Wallace, Aaron S.; Mitgang, Elizabeth A.; Leonard, Jim; Bartsch, Sarah; Yemeke, Tatenda T.; Zenkov, Eli; Ozawa, Sachiko.
In: Vaccine, Vol. 37, No. 17, 17.04.2019, p. 2377-2386.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Economic value of vaccinating geographically hard-to-reach populations with measles vaccine
T2 - A modeling application in Kenya
AU - Lee, Bruce
AU - Brown, Shawn T.
AU - Haidari, Leila A.
AU - Clark, Samantha
AU - Abimbola, Taiwo
AU - Pallas, Sarah E.
AU - Wallace, Aaron S.
AU - Mitgang, Elizabeth A.
AU - Leonard, Jim
AU - Bartsch, Sarah
AU - Yemeke, Tatenda T.
AU - Zenkov, Eli
AU - Ozawa, Sachiko
PY - 2019/4/17
Y1 - 2019/4/17
N2 - Background: Since special efforts are necessary to vaccinate people living far from fixed vaccination posts, decision makers are interested in knowing the economic value of such efforts. Methods: Using our immunization geospatial information system platform and a measles compartment model, we quantified the health and economic value of a 2-dose measles immunization outreach strategy for children <24 months of age in Kenya who are geographically hard-to-reach (i.e., those living outside a specified catchment radius from fixed vaccination posts, which served as a proxy for access to services). Findings: When geographically hard-to-reach children were not vaccinated, there were 1427 total measles cases from 2016 to 2020, resulting in $9.5 million ($3.1–$18.1 million) in direct medical costs and productivity losses and 7504 (3338–12,903) disability-adjusted life years (DALYs). The outreach strategy cost $76 ($23–$142)/DALY averted (compared to no outreach) when 25% of geographically hard-to-reach children received MCV1, $122 ($40-$226)/DALY averted when 50% received MCV1, and $274 ($123-$478)/DALY averted when 100% received MCV1. Conclusion: Outreach vaccination among geographically hard-to-reach populations was highly cost-effective in a wide variety of scenarios, offering support for investment in an effective outreach vaccination strategy.
AB - Background: Since special efforts are necessary to vaccinate people living far from fixed vaccination posts, decision makers are interested in knowing the economic value of such efforts. Methods: Using our immunization geospatial information system platform and a measles compartment model, we quantified the health and economic value of a 2-dose measles immunization outreach strategy for children <24 months of age in Kenya who are geographically hard-to-reach (i.e., those living outside a specified catchment radius from fixed vaccination posts, which served as a proxy for access to services). Findings: When geographically hard-to-reach children were not vaccinated, there were 1427 total measles cases from 2016 to 2020, resulting in $9.5 million ($3.1–$18.1 million) in direct medical costs and productivity losses and 7504 (3338–12,903) disability-adjusted life years (DALYs). The outreach strategy cost $76 ($23–$142)/DALY averted (compared to no outreach) when 25% of geographically hard-to-reach children received MCV1, $122 ($40-$226)/DALY averted when 50% received MCV1, and $274 ($123-$478)/DALY averted when 100% received MCV1. Conclusion: Outreach vaccination among geographically hard-to-reach populations was highly cost-effective in a wide variety of scenarios, offering support for investment in an effective outreach vaccination strategy.
KW - Economic
KW - Hard-to-reach populations
KW - Vaccination
UR - http://www.scopus.com/inward/record.url?scp=85063294118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063294118&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2019.03.007
DO - 10.1016/j.vaccine.2019.03.007
M3 - Article
VL - 37
SP - 2377
EP - 2386
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 17
ER -