Economic value of vaccinating geographically hard-to-reach populations with measles vaccine

A modeling application in Kenya

Bruce Lee, Shawn T. Brown, Leila A. Haidari, Samantha Clark, Taiwo Abimbola, Sarah E. Pallas, Aaron S. Wallace, Elizabeth A. Mitgang, Jim Leonard, Sarah Bartsch, Tatenda T. Yemeke, Eli Zenkov, Sachiko Ozawa

Research output: Contribution to journalArticle

Abstract

Background: Since special efforts are necessary to vaccinate people living far from fixed vaccination posts, decision makers are interested in knowing the economic value of such efforts. Methods: Using our immunization geospatial information system platform and a measles compartment model, we quantified the health and economic value of a 2-dose measles immunization outreach strategy for children <24 months of age in Kenya who are geographically hard-to-reach (i.e., those living outside a specified catchment radius from fixed vaccination posts, which served as a proxy for access to services). Findings: When geographically hard-to-reach children were not vaccinated, there were 1427 total measles cases from 2016 to 2020, resulting in $9.5 million ($3.1–$18.1 million) in direct medical costs and productivity losses and 7504 (3338–12,903) disability-adjusted life years (DALYs). The outreach strategy cost $76 ($23–$142)/DALY averted (compared to no outreach) when 25% of geographically hard-to-reach children received MCV1, $122 ($40-$226)/DALY averted when 50% received MCV1, and $274 ($123-$478)/DALY averted when 100% received MCV1. Conclusion: Outreach vaccination among geographically hard-to-reach populations was highly cost-effective in a wide variety of scenarios, offering support for investment in an effective outreach vaccination strategy.

Original languageEnglish (US)
Pages (from-to)2377-2386
Number of pages10
JournalVaccine
Volume37
Issue number17
DOIs
StatePublished - Apr 17 2019

Fingerprint

Measles Vaccine
outreach
disability-adjusted life year
Quality-Adjusted Life Years
Kenya
economic valuation
Measles
Vaccination
Economics
vaccines
vaccination
Costs and Cost Analysis
Population
Immunization
immunization
Proxy
Information Systems
geographic information systems
Health
dosage

Keywords

  • Economic
  • Hard-to-reach populations
  • Vaccination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Economic value of vaccinating geographically hard-to-reach populations with measles vaccine : A modeling application in Kenya. / Lee, Bruce; Brown, Shawn T.; Haidari, Leila A.; Clark, Samantha; Abimbola, Taiwo; Pallas, Sarah E.; Wallace, Aaron S.; Mitgang, Elizabeth A.; Leonard, Jim; Bartsch, Sarah; Yemeke, Tatenda T.; Zenkov, Eli; Ozawa, Sachiko.

In: Vaccine, Vol. 37, No. 17, 17.04.2019, p. 2377-2386.

Research output: Contribution to journalArticle

Lee, B, Brown, ST, Haidari, LA, Clark, S, Abimbola, T, Pallas, SE, Wallace, AS, Mitgang, EA, Leonard, J, Bartsch, S, Yemeke, TT, Zenkov, E & Ozawa, S 2019, 'Economic value of vaccinating geographically hard-to-reach populations with measles vaccine: A modeling application in Kenya', Vaccine, vol. 37, no. 17, pp. 2377-2386. https://doi.org/10.1016/j.vaccine.2019.03.007
Lee, Bruce ; Brown, Shawn T. ; Haidari, Leila A. ; Clark, Samantha ; Abimbola, Taiwo ; Pallas, Sarah E. ; Wallace, Aaron S. ; Mitgang, Elizabeth A. ; Leonard, Jim ; Bartsch, Sarah ; Yemeke, Tatenda T. ; Zenkov, Eli ; Ozawa, Sachiko. / Economic value of vaccinating geographically hard-to-reach populations with measles vaccine : A modeling application in Kenya. In: Vaccine. 2019 ; Vol. 37, No. 17. pp. 2377-2386.
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