Economic Impact of Potential CYP450 Pharmacokinetic Drug-Drug Interactions Among Chronic Low Back Pain Patients Taking Opioids

Joseph V. Pergolizzi, Sumedha A. Labhsetwar, R. Amy Puenpatom, Rami Ben-Joseph, Robert Ohsfeldt, Kent H. Summers

Research output: Contribution to journalArticle

Abstract

Chronic low back pain (cLBP) patients who take at least 1 CYP450-metabolized opioid analgesic agent concurrent with at least 1 other CYP450-metabolized medication experience a drug-drug exposure (DDE), which puts them at risk for a pharmacokinetic drug-drug interaction (PK DDI). This study compared utilization of healthcare resources and associated payments in cLBP patients with and without incident DDEs with the potential to cause PK DDIs. A retrospective database analysis examined the associated clinical events, healthcare utilization (measured in terms of claims for office visits, outpatient visits, emergency department visits, and hospitalization), and cost to the health plan, as defined as the sum of health plan payments for resources used. Patients were grouped into 2 cohorts by age (those under 65 and those 65years and over). In the 6months after exposure, total healthcare payments were significantly higher for DDE patients than those without DDEs (no-DDE), in both in the younger ($7,086, SD=$8,370) and $6,353, SD=$8,352, respectively, P

Original languageEnglish (US)
Pages (from-to)45-56
Number of pages12
JournalPain Practice
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Keywords

  • Analgesics
  • Back pain
  • Low back pain
  • Lower back pain
  • Narcotics
  • Opioid
  • Opioid analgesics
  • Pharmacologic actions
  • Therapeutics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Pergolizzi, J. V., Labhsetwar, S. A., Amy Puenpatom, R., Ben-Joseph, R., Ohsfeldt, R., & Summers, K. H. (2012). Economic Impact of Potential CYP450 Pharmacokinetic Drug-Drug Interactions Among Chronic Low Back Pain Patients Taking Opioids. Pain Practice, 12(1), 45-56. https://doi.org/10.1111/j.1533-2500.2011.00503.x