Abstract
The study was done to evaluate the cost-effectiveness of a national rotavirus vaccination programme in Brazilian children from the healthcare system perspective. A hypothetical annual birth-cohort was followed for a five-year period. Published and national administrative data were incorporated into a model to quantify the consequences of vaccination versus no vaccination. Main outcome measures included the reduction in disease burden, lives saved, and disability-adjusted life-years (DALYs) averted. A rotavirus vaccination programme in Brazil would prevent an estimated 1,804 deaths associated with gastroenteritis due to rotavirus, 91,127 hospitalizations, and 550,198 outpatient visits. Vaccination is likely to reduce 76% of the overall healthcare burden of rotavirus-associated gastroenteritis in Brazil. At a vaccine price of US$7-8 per dose, the cost-effectiveness ratio would be US$ 643 per DALY averted. Rotavirus vaccination can reduce the burden of gastroenteritis due to rotavirus at a reasonable cost-effectiveness ratio.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 388-396 |
| Number of pages | 9 |
| Journal | Journal of Health, Population and Nutrition |
| Volume | 26 |
| Issue number | 4 |
| State | Published - 2008 |
| Externally published | Yes |
Keywords
- Brazil
- Costs and cost analysis
- Diarrhoea
- Gastroenteritis
- Infatile
- Morbidity
- Rotavirus
- Rotavirus vaccines
- Vaccination
ASJC Scopus subject areas
- Food Science
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis