Economic impact of a rotavirus vaccine in Brazil

Dagna O. Constenla, Alexandre C. Linhares, Richard D. Rheingans, Lynn R. Antil, Eliseu A. Waldman, Luiz J. da Silva

Research output: Contribution to journalArticlepeer-review


The study was done to evaluate the cost-effectiveness of a national rotavirus vaccination programme in Brazilian children from the healthcare system perspective. A hypothetical annual birth-cohort was followed for a five-year period. Published and national administrative data were incorporated into a model to quantify the consequences of vaccination versus no vaccination. Main outcome measures included the reduction in disease burden, lives saved, and disability-adjusted life-years (DALYs) averted. A rotavirus vaccination programme in Brazil would prevent an estimated 1,804 deaths associated with gastroenteritis due to rotavirus, 91,127 hospitalizations, and 550,198 outpatient visits. Vaccination is likely to reduce 76% of the overall healthcare burden of rotavirus-associated gastroenteritis in Brazil. At a vaccine price of US$7-8 per dose, the cost-effectiveness ratio would be US$ 643 per DALY averted. Rotavirus vaccination can reduce the burden of gastroenteritis due to rotavirus at a reasonable cost-effectiveness ratio.

Original languageEnglish (US)
Pages (from-to)388-396
Number of pages9
JournalJournal of Health, Population and Nutrition
Issue number4
StatePublished - 2008
Externally publishedYes


  • Brazil
  • Costs and cost analysis
  • Diarrhoea
  • Gastroenteritis
  • Infatile
  • Morbidity
  • Rotavirus
  • Rotavirus vaccines
  • Vaccination

ASJC Scopus subject areas

  • Food Science
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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