Echo-doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease

Mohammed Alghamdi, Astrid M. De Souza, Colin T. White, M. Terri Potts, Bradley A. Warady, Susan L. Furth, Thomas R. Kimball, James E. Potts, George G S Sandor

Research output: Contribution to journalArticle

Abstract

Chronic kidney disease (CKD) is known to cause increased arterial stiffness, which is an important independent risk factor for adverse cardiovascular events. The purpose of this study was to assess the vascular properties of the aorta (AO) in a group of children with CKD using a noninvasive echocardiography (echo)-Doppler method. We studied 24 children with stages 2 through 5 CKD and 48 age-matched controls. Detailed echocardiographic assessment and echo-Doppler pulse wave velocity (PWV) was performed. Indices of arterial stiffness, including characteristic (Zc) and input (Zi) impedances, elastic pressure-strain modulus (Ep), and arterial wall stiffness index, were calculated. CKD patients underwent full nephrology assessment, and an iohexol glomerular filtration rate was performed, which allowed for accurate assignment of the CKD stage. CKD patients had greater median systolic blood pressure (114 vs. 110 mmHg; p <0.04) and pulse pressure (51 vs. 40 mmHg; p <0.001) compared with controls. PWV was similar between groups (358 vs. 344 cm s -1; p = 0.759), whereas Zi (182 vs. 131 dyne s cm-5; p <0.001), Zc (146 vs. 138 dyne s cm-5; p = 0.05), and Ep (280 vs. 230 mmHg; p <0.02) were significantly greater in CKD than in controls. Although load-dependent measures of arterial stiffness were greater in non-dialysis dependent CKD patients, PWV was not increased compared with controls. This suggests that the increased arterial stiffness may not be permanent in these pediatric patients with kidney disease.

Original languageEnglish (US)
Pages (from-to)1218-1225
Number of pages8
JournalPediatric Cardiology
Volume34
Issue number5
DOIs
StatePublished - Jun 2013
Externally publishedYes

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Chronic Renal Insufficiency
Aorta
Vascular Stiffness
Pulse Wave Analysis
Doppler Echocardiography
Blood Pressure
Iohexol
Nephrology
Kidney Diseases
Electric Impedance
Glomerular Filtration Rate
Blood Vessels
Pediatrics
Pressure

Keywords

  • Aorta
  • Arterial stiffness
  • Children
  • Echocardiography
  • Kidney disease
  • Pulse wave velocity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Alghamdi, M., De Souza, A. M., White, C. T., Potts, M. T., Warady, B. A., Furth, S. L., ... Sandor, G. G. S. (2013). Echo-doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease. Pediatric Cardiology, 34(5), 1218-1225. https://doi.org/10.1007/s00246-013-0632-5

Echo-doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease. / Alghamdi, Mohammed; De Souza, Astrid M.; White, Colin T.; Potts, M. Terri; Warady, Bradley A.; Furth, Susan L.; Kimball, Thomas R.; Potts, James E.; Sandor, George G S.

In: Pediatric Cardiology, Vol. 34, No. 5, 06.2013, p. 1218-1225.

Research output: Contribution to journalArticle

Alghamdi, M, De Souza, AM, White, CT, Potts, MT, Warady, BA, Furth, SL, Kimball, TR, Potts, JE & Sandor, GGS 2013, 'Echo-doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease', Pediatric Cardiology, vol. 34, no. 5, pp. 1218-1225. https://doi.org/10.1007/s00246-013-0632-5
Alghamdi, Mohammed ; De Souza, Astrid M. ; White, Colin T. ; Potts, M. Terri ; Warady, Bradley A. ; Furth, Susan L. ; Kimball, Thomas R. ; Potts, James E. ; Sandor, George G S. / Echo-doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease. In: Pediatric Cardiology. 2013 ; Vol. 34, No. 5. pp. 1218-1225.
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