Echo-doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease

Mohammed Alghamdi; Astrid M. De Souza; Colin T. White; M. Terri Potts; Bradley A. Warady; Susan L. Furth; Thomas R. Kimball; James E. Potts; George G.S. Sandor

doi:10.1007/s00246-013-0632-5

Echo-doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease

Mohammed Alghamdi, Astrid M. De Souza, Colin T. White, M. Terri Potts, Bradley A. Warady, Susan L. Furth, Thomas R. Kimball, James E. Potts, George G.S. Sandor

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Chronic kidney disease (CKD) is known to cause increased arterial stiffness, which is an important independent risk factor for adverse cardiovascular events. The purpose of this study was to assess the vascular properties of the aorta (AO) in a group of children with CKD using a noninvasive echocardiography (echo)-Doppler method. We studied 24 children with stages 2 through 5 CKD and 48 age-matched controls. Detailed echocardiographic assessment and echo-Doppler pulse wave velocity (PWV) was performed. Indices of arterial stiffness, including characteristic (Zc) and input (Zi) impedances, elastic pressure-strain modulus (Ep), and arterial wall stiffness index, were calculated. CKD patients underwent full nephrology assessment, and an iohexol glomerular filtration rate was performed, which allowed for accurate assignment of the CKD stage. CKD patients had greater median systolic blood pressure (114 vs. 110 mmHg; p < 0.04) and pulse pressure (51 vs. 40 mmHg; p < 0.001) compared with controls. PWV was similar between groups (358 vs. 344 cm s ^-1; p = 0.759), whereas Zi (182 vs. 131 dyne s cm^-5; p < 0.001), Zc (146 vs. 138 dyne s cm^-5; p = 0.05), and Ep (280 vs. 230 mmHg; p < 0.02) were significantly greater in CKD than in controls. Although load-dependent measures of arterial stiffness were greater in non-dialysis dependent CKD patients, PWV was not increased compared with controls. This suggests that the increased arterial stiffness may not be permanent in these pediatric patients with kidney disease.

Original language	English (US)
Pages (from-to)	1218-1225
Number of pages	8
Journal	Pediatric Cardiology
Volume	34
Issue number	5
DOIs	https://doi.org/10.1007/s00246-013-0632-5
State	Published - Jun 2013
Externally published	Yes

Keywords

Aorta
Arterial stiffness
Children
Echocardiography
Kidney disease
Pulse wave velocity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Cardiology and Cardiovascular Medicine

Access to Document

10.1007/s00246-013-0632-5

Cite this

@article{86e62ab317534f8291c77bf198914a40,

title = "Echo-doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease",

abstract = "Chronic kidney disease (CKD) is known to cause increased arterial stiffness, which is an important independent risk factor for adverse cardiovascular events. The purpose of this study was to assess the vascular properties of the aorta (AO) in a group of children with CKD using a noninvasive echocardiography (echo)-Doppler method. We studied 24 children with stages 2 through 5 CKD and 48 age-matched controls. Detailed echocardiographic assessment and echo-Doppler pulse wave velocity (PWV) was performed. Indices of arterial stiffness, including characteristic (Zc) and input (Zi) impedances, elastic pressure-strain modulus (Ep), and arterial wall stiffness index, were calculated. CKD patients underwent full nephrology assessment, and an iohexol glomerular filtration rate was performed, which allowed for accurate assignment of the CKD stage. CKD patients had greater median systolic blood pressure (114 vs. 110 mmHg; p < 0.04) and pulse pressure (51 vs. 40 mmHg; p < 0.001) compared with controls. PWV was similar between groups (358 vs. 344 cm s -1; p = 0.759), whereas Zi (182 vs. 131 dyne s cm-5; p < 0.001), Zc (146 vs. 138 dyne s cm-5; p = 0.05), and Ep (280 vs. 230 mmHg; p < 0.02) were significantly greater in CKD than in controls. Although load-dependent measures of arterial stiffness were greater in non-dialysis dependent CKD patients, PWV was not increased compared with controls. This suggests that the increased arterial stiffness may not be permanent in these pediatric patients with kidney disease.",

keywords = "Aorta, Arterial stiffness, Children, Echocardiography, Kidney disease, Pulse wave velocity",

author = "Mohammed Alghamdi and {De Souza}, {Astrid M.} and White, {Colin T.} and Potts, {M. Terri} and Warady, {Bradley A.} and Furth, {Susan L.} and Kimball, {Thomas R.} and Potts, {James E.} and Sandor, {George G.S.}",

note = "Funding Information: The CKiD Study is funded by the National Institute of Diabetes and Digestive and Kidney Diseases with additional funding from the National Institute of Neurologic Disorders and Stroke; the National Institute of Child Health and Human Development; and the National Heart, Lung, and Blood Institute (Grants No. UO1-DK-66143, UO1-DK-66174, UO1-DK-66116, and U01-DK-082194). GE Health Care, Amersham Division, provided iohexol for the GFR measurements. The CKID web site is located at http://www.statepi.jhsph.edu/ckid . We thank Josephine Chow for invaluable assistance in coordinating all of the CKiD investigations locally. ",

year = "2013",

month = jun,

doi = "10.1007/s00246-013-0632-5",

language = "English (US)",

volume = "34",

pages = "1218--1225",

journal = "Pediatric Cardiology",

issn = "0172-0643",

publisher = "Springer New York",

number = "5",

}

TY - JOUR

T1 - Echo-doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease

AU - Alghamdi, Mohammed

AU - De Souza, Astrid M.

AU - White, Colin T.

AU - Potts, M. Terri

AU - Warady, Bradley A.

AU - Furth, Susan L.

AU - Kimball, Thomas R.

AU - Potts, James E.

AU - Sandor, George G.S.

N1 - Funding Information: The CKiD Study is funded by the National Institute of Diabetes and Digestive and Kidney Diseases with additional funding from the National Institute of Neurologic Disorders and Stroke; the National Institute of Child Health and Human Development; and the National Heart, Lung, and Blood Institute (Grants No. UO1-DK-66143, UO1-DK-66174, UO1-DK-66116, and U01-DK-082194). GE Health Care, Amersham Division, provided iohexol for the GFR measurements. The CKID web site is located at http://www.statepi.jhsph.edu/ckid . We thank Josephine Chow for invaluable assistance in coordinating all of the CKiD investigations locally.

PY - 2013/6

Y1 - 2013/6

N2 - Chronic kidney disease (CKD) is known to cause increased arterial stiffness, which is an important independent risk factor for adverse cardiovascular events. The purpose of this study was to assess the vascular properties of the aorta (AO) in a group of children with CKD using a noninvasive echocardiography (echo)-Doppler method. We studied 24 children with stages 2 through 5 CKD and 48 age-matched controls. Detailed echocardiographic assessment and echo-Doppler pulse wave velocity (PWV) was performed. Indices of arterial stiffness, including characteristic (Zc) and input (Zi) impedances, elastic pressure-strain modulus (Ep), and arterial wall stiffness index, were calculated. CKD patients underwent full nephrology assessment, and an iohexol glomerular filtration rate was performed, which allowed for accurate assignment of the CKD stage. CKD patients had greater median systolic blood pressure (114 vs. 110 mmHg; p < 0.04) and pulse pressure (51 vs. 40 mmHg; p < 0.001) compared with controls. PWV was similar between groups (358 vs. 344 cm s -1; p = 0.759), whereas Zi (182 vs. 131 dyne s cm-5; p < 0.001), Zc (146 vs. 138 dyne s cm-5; p = 0.05), and Ep (280 vs. 230 mmHg; p < 0.02) were significantly greater in CKD than in controls. Although load-dependent measures of arterial stiffness were greater in non-dialysis dependent CKD patients, PWV was not increased compared with controls. This suggests that the increased arterial stiffness may not be permanent in these pediatric patients with kidney disease.

AB - Chronic kidney disease (CKD) is known to cause increased arterial stiffness, which is an important independent risk factor for adverse cardiovascular events. The purpose of this study was to assess the vascular properties of the aorta (AO) in a group of children with CKD using a noninvasive echocardiography (echo)-Doppler method. We studied 24 children with stages 2 through 5 CKD and 48 age-matched controls. Detailed echocardiographic assessment and echo-Doppler pulse wave velocity (PWV) was performed. Indices of arterial stiffness, including characteristic (Zc) and input (Zi) impedances, elastic pressure-strain modulus (Ep), and arterial wall stiffness index, were calculated. CKD patients underwent full nephrology assessment, and an iohexol glomerular filtration rate was performed, which allowed for accurate assignment of the CKD stage. CKD patients had greater median systolic blood pressure (114 vs. 110 mmHg; p < 0.04) and pulse pressure (51 vs. 40 mmHg; p < 0.001) compared with controls. PWV was similar between groups (358 vs. 344 cm s -1; p = 0.759), whereas Zi (182 vs. 131 dyne s cm-5; p < 0.001), Zc (146 vs. 138 dyne s cm-5; p = 0.05), and Ep (280 vs. 230 mmHg; p < 0.02) were significantly greater in CKD than in controls. Although load-dependent measures of arterial stiffness were greater in non-dialysis dependent CKD patients, PWV was not increased compared with controls. This suggests that the increased arterial stiffness may not be permanent in these pediatric patients with kidney disease.

KW - Aorta

KW - Arterial stiffness

KW - Children

KW - Echocardiography

KW - Kidney disease

KW - Pulse wave velocity

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JO - Pediatric Cardiology

JF - Pediatric Cardiology

IS - 5

ER -

Echo-doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease

Abstract

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ASJC Scopus subject areas

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