Echinocandins

Andreas H. Groll, Dominik Schrey, Thomas J. Walsh

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Ever since the discovery that penicillin inhibits bacterial cell wall synthesis, developing equivalent agents to target the fungal cell wall has been a focus of antifungal drug development. Because the cell wall is essential to the vitality of fungal organisms and because its components are absent in the mammalian host, the fungal cell wall represents an ideal target for antifungal compounds. With considerable variation among different species, the gross macromolecular components of the cell wall of most fungi include chitin, alpha- or beta-linked glucans, and a variety of mannoproteins. The dynamics of the fungal cell wall are closely coordinated with cell growth and cell division, and the predominant function of the cell wall is to control the internal turgor of the cell. Disruption of the cell wall structure leads to osmotic instability and may ultimately result in the lysis of the fungal cell. The echinocandins are antifungal agents whose actions are directed against the major constituents of the fungal cell wall.

Original languageEnglish (US)
Title of host publicationEssentials of Clinical Mycology
Subtitle of host publicationSecond Edition
PublisherSpringer New York
Pages95-112
Number of pages18
ISBN (Electronic)9781441966407
ISBN (Print)9781441966391
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'Echinocandins'. Together they form a unique fingerprint.

Cite this