EBV-associated recurrent Hodgkin's disease after renal transplantation

Katherine H. Flanagan, Daniel Brennan

Research output: Contribution to journalArticle

Abstract

Hodgkin's disease is recognized as part of the spectrum of post-transplantation lymphoproliferative disorders (PTLD), although it is still an uncommon de novo malignancy in this population. Epstein-Barr virus (EBV) has been linked to both post-transplant non-Hodgkin's lymphomas and Hodgkin's disease. We report a case of recurrent Hodgkin's disease in a patient who received a renal transplant in childhood and later developed EBV-associated Hodgkin's disease with remission after chemotherapy until subsequent relapse 9 years later that was successfully treated. To our knowledge, this is the first report of recurrent Hodgkin's disease in a transplant recipient. We briefly discuss the pathogenesis of and risk factors for EBV-related PTLD, utility of EBV load surveillance, and the options for treatment of PTLD including immunosuppression reduction, antiviral therapy, anti-CD20 monoclonal antibodies, cytotoxic T cells, and the possible roles of interferon-α and rapamycin.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalTransplant International
Volume19
Issue number4
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

Fingerprint

Human Herpesvirus 4
Hodgkin Disease
Kidney Transplantation
Lymphoproliferative Disorders
Transplantation
Transplants
Sirolimus
Non-Hodgkin's Lymphoma
Immunosuppression
Interferons
Antiviral Agents
Monoclonal Antibodies
T-Lymphocytes
Kidney
Recurrence
Drug Therapy
Therapeutics
Population
Neoplasms

Keywords

  • Epstein-Barr virus
  • Hodgkin's disease
  • Kidney transplant
  • Post-transplant lymphoproliferative disease
  • Recurrence

ASJC Scopus subject areas

  • Transplantation

Cite this

EBV-associated recurrent Hodgkin's disease after renal transplantation. / Flanagan, Katherine H.; Brennan, Daniel.

In: Transplant International, Vol. 19, No. 4, 01.04.2006, p. 338-341.

Research output: Contribution to journalArticle

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