EBV-associated lymphoma and chronic inflammatory demyelinating polyneuropathy in an adult without overt immunodeficiency

Yvette L. Kasamon, Thanh N. Nguyen, Jennifer A. Chan, Alessandra F. Nascimento

Research output: Contribution to journalArticlepeer-review

Abstract

Epstein-Barr virus (EBV)-associated lymphoproliferative disease occurs almost exclusively in immunocompromised states. This type of malignancy nevertheless developed in a woman without overt immunocompromise. She presented with rapidly progressive lower extremity weakness that was consistent with a chronic inflammatory demyelinating polyneuropathy (CIDP). CIDP has been documented in Hodgkin's disease but rarely in non-Hodgkin's disease. Diagnosis was confirmed by lymph node and sural nerve biopsies and by nerve conduction studies. Prednisone, rituximab, cyclophosphamide, doxorubicin, and etoposide were administered with regression of lymphadenopathy and improvement in neurologic symptoms. EBV-associated lymphoproliferative disease can thus develop in the absence of overt immunodeficiency and may trigger a demyelinating polyneuropathy.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalAmerican Journal of Hematology
Volume69
Issue number4
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Chronic inflammatory demyelinating polyneuropathy
  • Epstein-Barr virus

ASJC Scopus subject areas

  • Hematology

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