Ebselen effects on MPTP-induced neurotoxicity

Muralikrishnan Dhanasekaran; Subramaniam Uthayathas; Senthilkumar S. Karuppagounder; Kodeeswaran Parameshwaran; Vishnu Suppiramaniam; Manuchair Ebadi; Holly M. Brown-Borg

doi:10.1016/j.brainres.2006.08.020

Ebselen effects on MPTP-induced neurotoxicity

Muralikrishnan Dhanasekaran, Subramaniam Uthayathas, Senthilkumar S. Karuppagounder, Kodeeswaran Parameshwaran, Vishnu Suppiramaniam, Manuchair Ebadi, Holly M. Brown-Borg

Research output: Contribution to journal › Article

Abstract

We evaluated the effect of ebselen on human SH-SY5Y dopaminergic neuronal cells and determined whether ebselen, a glutathione peroxidase-mimetic, protected against MPTP-induced dopamine depletion in mice. Ebselen (10-100 μM) inhibited the proliferation of SH-SY5Y cells dose-dependently. Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum.

Original language	English (US)
Pages (from-to)	251-254
Number of pages	4
Journal	Brain research
Volume	1118
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2006.08.020
State	Published - Nov 6 2006
Externally published	Yes

Keywords

Ebselen
MPTP
Monoamine oxidase
Neuroprotection
SH-SY5Y cell

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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Dhanasekaran, M., Uthayathas, S., Karuppagounder, S. S., Parameshwaran, K., Suppiramaniam, V., Ebadi, M., & Brown-Borg, H. M. (2006). Ebselen effects on MPTP-induced neurotoxicity. Brain research, 1118(1), 251-254. https://doi.org/10.1016/j.brainres.2006.08.020

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AU - Dhanasekaran, Muralikrishnan

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AU - Parameshwaran, Kodeeswaran

AU - Suppiramaniam, Vishnu

AU - Ebadi, Manuchair

AU - Brown-Borg, Holly M.

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