Ebselen effects on MPTP-induced neurotoxicity

Muralikrishnan Dhanasekaran, Subramaniam Uthayathas, Senthilkumar S. Karuppagounder, Kodeeswaran Parameshwaran, Vishnu Suppiramaniam, Manuchair Ebadi, Holly M. Brown-Borg

Research output: Contribution to journalArticle

Abstract

We evaluated the effect of ebselen on human SH-SY5Y dopaminergic neuronal cells and determined whether ebselen, a glutathione peroxidase-mimetic, protected against MPTP-induced dopamine depletion in mice. Ebselen (10-100 μM) inhibited the proliferation of SH-SY5Y cells dose-dependently. Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum.

Original languageEnglish (US)
Pages (from-to)251-254
Number of pages4
JournalBrain research
Volume1118
Issue number1
DOIs
StatePublished - Nov 6 2006
Externally publishedYes

Keywords

  • Ebselen
  • MPTP
  • Monoamine oxidase
  • Neuroprotection
  • SH-SY5Y cell

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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  • Cite this

    Dhanasekaran, M., Uthayathas, S., Karuppagounder, S. S., Parameshwaran, K., Suppiramaniam, V., Ebadi, M., & Brown-Borg, H. M. (2006). Ebselen effects on MPTP-induced neurotoxicity. Brain research, 1118(1), 251-254. https://doi.org/10.1016/j.brainres.2006.08.020