TY - JOUR
T1 - Ebselen effects on MPTP-induced neurotoxicity
AU - Dhanasekaran, Muralikrishnan
AU - Uthayathas, Subramaniam
AU - Karuppagounder, Senthilkumar S.
AU - Parameshwaran, Kodeeswaran
AU - Suppiramaniam, Vishnu
AU - Ebadi, Manuchair
AU - Brown-Borg, Holly M.
N1 - Funding Information:
This study was supported by Department of Pharmacal Sciences, Auburn University, Auburn, AL and National Institute of Neurological Disorders and Stroke, 2R01 NS 34566-09.
PY - 2006/11/6
Y1 - 2006/11/6
N2 - We evaluated the effect of ebselen on human SH-SY5Y dopaminergic neuronal cells and determined whether ebselen, a glutathione peroxidase-mimetic, protected against MPTP-induced dopamine depletion in mice. Ebselen (10-100 μM) inhibited the proliferation of SH-SY5Y cells dose-dependently. Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum.
AB - We evaluated the effect of ebselen on human SH-SY5Y dopaminergic neuronal cells and determined whether ebselen, a glutathione peroxidase-mimetic, protected against MPTP-induced dopamine depletion in mice. Ebselen (10-100 μM) inhibited the proliferation of SH-SY5Y cells dose-dependently. Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum.
KW - Ebselen
KW - MPTP
KW - Monoamine oxidase
KW - Neuroprotection
KW - SH-SY5Y cell
UR - http://www.scopus.com/inward/record.url?scp=33750371842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750371842&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2006.08.020
DO - 10.1016/j.brainres.2006.08.020
M3 - Article
C2 - 16956591
AN - SCOPUS:33750371842
VL - 1118
SP - 251
EP - 254
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -