Early warning indicators for first-line virologic failure independent of adherence measures in a South African Urban clinic

Vincent C. Marconi, Baohua Wu, Jane Hampton, Claudia E. Ordóñez, Brent A. Johnson, Dinesh Singh, Sally John, Michelle Gordon, Anna Hare, Richard Murphy, Jean Nachega, Daniel R. Kuritzkes, Carlos Del Rio, Henry Sunpath

Research output: Contribution to journalArticle

Abstract

We sought to develop individual-level Early Warning Indicators (EWI) of virologic failure (VF) for clinicians to use during routine care complementing WHO population-level EWI. A case-control study was conducted at a Durban clinic. Patients after≥5 months of first-line antiretroviral therapy (ART) were defined as cases if they had VF [HIV-1 viral load (VL)>1000 copies/mL] and controls (2:1) if they had VL≤1000 copies/mL. Pharmacy refills and pill counts were used as adherence measures. Participants responded to a questionnaire including validated psychosocial and symptom scales. Data were also collected from the medical record. Multivariable logistic regression models of VF included factors associated with VF (p

Original languageEnglish (US)
Pages (from-to)657-668
Number of pages12
JournalAIDS Patient Care and STDs
Volume27
Issue number12
DOIs
StatePublished - Dec 1 2013

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Logistic Models
Viral Load
Medical Records
HIV-1
Case-Control Studies
Population
Therapeutics
Surveys and Questionnaires

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Marconi, V. C., Wu, B., Hampton, J., Ordóñez, C. E., Johnson, B. A., Singh, D., ... Sunpath, H. (2013). Early warning indicators for first-line virologic failure independent of adherence measures in a South African Urban clinic. AIDS Patient Care and STDs, 27(12), 657-668. https://doi.org/10.1089/apc.2013.0263

Early warning indicators for first-line virologic failure independent of adherence measures in a South African Urban clinic. / Marconi, Vincent C.; Wu, Baohua; Hampton, Jane; Ordóñez, Claudia E.; Johnson, Brent A.; Singh, Dinesh; John, Sally; Gordon, Michelle; Hare, Anna; Murphy, Richard; Nachega, Jean; Kuritzkes, Daniel R.; Del Rio, Carlos; Sunpath, Henry.

In: AIDS Patient Care and STDs, Vol. 27, No. 12, 01.12.2013, p. 657-668.

Research output: Contribution to journalArticle

Marconi, VC, Wu, B, Hampton, J, Ordóñez, CE, Johnson, BA, Singh, D, John, S, Gordon, M, Hare, A, Murphy, R, Nachega, J, Kuritzkes, DR, Del Rio, C & Sunpath, H 2013, 'Early warning indicators for first-line virologic failure independent of adherence measures in a South African Urban clinic', AIDS Patient Care and STDs, vol. 27, no. 12, pp. 657-668. https://doi.org/10.1089/apc.2013.0263
Marconi, Vincent C. ; Wu, Baohua ; Hampton, Jane ; Ordóñez, Claudia E. ; Johnson, Brent A. ; Singh, Dinesh ; John, Sally ; Gordon, Michelle ; Hare, Anna ; Murphy, Richard ; Nachega, Jean ; Kuritzkes, Daniel R. ; Del Rio, Carlos ; Sunpath, Henry. / Early warning indicators for first-line virologic failure independent of adherence measures in a South African Urban clinic. In: AIDS Patient Care and STDs. 2013 ; Vol. 27, No. 12. pp. 657-668.
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