Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) with a History of Coinfection with Human Immunodeficiency Virus Type 1 and Hepatitis C Virus

Juanjuan Zhao, Xuejiao Liao, Haiyan Wang, Lanlan Wei, Mingzhao Xing, Lei Liu, Zheng Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of host immune status on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. Here, we report the first case of coronavirus disease 2019 (COVID-19) with human immunodeficiency virus type 1 (HIV-1)/hepatitis C virus coinfection, who showed a persistently negative SARS-CoV-2 RNA test but delayed antibody response in the plasma. This case highlights the influence of HIV-1-induced immune dysfunction on early SARS-CoV-2 clearance.

Original languageEnglish (US)
Pages (from-to)2233-2235
Number of pages3
JournalClinical Infectious Diseases
Volume71
Issue number16
DOIs
StatePublished - Oct 15 2020
Externally publishedYes

Keywords

  • COVID-19
  • HCV
  • HIV-1
  • SARS-CoV-2
  • antibody

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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