Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) with a History of Coinfection with Human Immunodeficiency Virus Type 1 and Hepatitis C Virus

Juanjuan Zhao; Xuejiao Liao; Haiyan Wang; Lanlan Wei; Mingzhao Xing; Lei Liu; Zheng Zhang

doi:10.1093/cid/ciaa408

Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) with a History of Coinfection with Human Immunodeficiency Virus Type 1 and Hepatitis C Virus

Juanjuan Zhao, Xuejiao Liao, Haiyan Wang, Lanlan Wei, Mingzhao Xing, Lei Liu, Zheng Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of host immune status on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. Here, we report the first case of coronavirus disease 2019 (COVID-19) with human immunodeficiency virus type 1 (HIV-1)/hepatitis C virus coinfection, who showed a persistently negative SARS-CoV-2 RNA test but delayed antibody response in the plasma. This case highlights the influence of HIV-1-induced immune dysfunction on early SARS-CoV-2 clearance.

Original language	English (US)
Pages (from-to)	2233-2235
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	71
Issue number	16
DOIs	https://doi.org/10.1093/cid/ciaa408
State	Published - Oct 15 2020
Externally published	Yes

Keywords

COVID-19
HCV
HIV-1
SARS-CoV-2
antibody

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciaa408

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Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) with a History of Coinfection with Human Immunodeficiency Virus Type 1 and Hepatitis C Virus. / Zhao, Juanjuan; Liao, Xuejiao; Wang, Haiyan; Wei, Lanlan; Xing, Mingzhao; Liu, Lei; Zhang, Zheng.

In: Clinical Infectious Diseases, Vol. 71, No. 16, 15.10.2020, p. 2233-2235.

Research output: Contribution to journal › Article › peer-review

Zhao, Juanjuan ; Liao, Xuejiao ; Wang, Haiyan ; Wei, Lanlan ; Xing, Mingzhao ; Liu, Lei ; Zhang, Zheng. / Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) with a History of Coinfection with Human Immunodeficiency Virus Type 1 and Hepatitis C Virus. In: Clinical Infectious Diseases. 2020 ; Vol. 71, No. 16. pp. 2233-2235.

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abstract = "The effect of host immune status on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. Here, we report the first case of coronavirus disease 2019 (COVID-19) with human immunodeficiency virus type 1 (HIV-1)/hepatitis C virus coinfection, who showed a persistently negative SARS-CoV-2 RNA test but delayed antibody response in the plasma. This case highlights the influence of HIV-1-induced immune dysfunction on early SARS-CoV-2 clearance. ",

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AU - Xing, Mingzhao

AU - Liu, Lei

AU - Zhang, Zheng

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Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) with a History of Coinfection with Human Immunodeficiency Virus Type 1 and Hepatitis C Virus

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