Early versus late surgical drainage for obstructive pancreatitis in an experimental model

B. Lamme, M. A. Boermeester, I. H. Straatsburg, J. M. Van Buijtenen, D. Boerma, G. J A Offerhaus, D. J. Gouma, T. M. Van Gulik

Research output: Contribution to journalArticle

Abstract

Background: Chronic pancreatitis (CP) is characterized by intractable abdominal pain, and pancreatic exocrine and endocrine dysfunction. This study investigated whether early surgical drainage of pancreatic duct obstruction leads to improved recovery of pancreatic function compared with late surgical drainage in an experimental model of chronic obstructive pancreatitis. Methods: Twenty-one piglets underwent pancreatic duct ligation and subsequent longitudinal pancreaticojejunostomy after 3 weeks (early drainage) or 6 weeks (late drainage), and drainage continued for 6 weeks. In controls with CP pancreatic duct ligation was continued for 12 weeks without a drainage procedure. Results: Histological pancreatitis scores decreased with early drainage (P = 0.005), but not with late drainage. Pancreatic secretion of amylase and lipase was restored after early but not late drainage (P = 0.003 and P = 0.048 respectively). Excretion levels of lipase were restored to near-baseline preligation levels after early drainage. Pancreatic endocrine function (glucose tolerance test) showed no insufficiency in either group. Conclusion: In this model of early versus late surgical drainage of obstructive pancreatitis, histology grades and pancreatic exocrine function showed improvement in the early drainage group but no recovery in the late drainage group.

Original languageEnglish (US)
Pages (from-to)849-854
Number of pages6
JournalBritish Journal of Surgery
Volume94
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

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Pancreatitis
Drainage
Theoretical Models
Pancreatic Ducts
Chronic Pancreatitis
Lipase
Ligation
Pancreaticojejunostomy
Intractable Pain
Recovery of Function
Amylases
Glucose Tolerance Test
Abdominal Pain
Histology

ASJC Scopus subject areas

  • Surgery

Cite this

Lamme, B., Boermeester, M. A., Straatsburg, I. H., Van Buijtenen, J. M., Boerma, D., Offerhaus, G. J. A., ... Van Gulik, T. M. (2007). Early versus late surgical drainage for obstructive pancreatitis in an experimental model. British Journal of Surgery, 94(7), 849-854. https://doi.org/10.1002/bjs.5722

Early versus late surgical drainage for obstructive pancreatitis in an experimental model. / Lamme, B.; Boermeester, M. A.; Straatsburg, I. H.; Van Buijtenen, J. M.; Boerma, D.; Offerhaus, G. J A; Gouma, D. J.; Van Gulik, T. M.

In: British Journal of Surgery, Vol. 94, No. 7, 07.2007, p. 849-854.

Research output: Contribution to journalArticle

Lamme, B, Boermeester, MA, Straatsburg, IH, Van Buijtenen, JM, Boerma, D, Offerhaus, GJA, Gouma, DJ & Van Gulik, TM 2007, 'Early versus late surgical drainage for obstructive pancreatitis in an experimental model', British Journal of Surgery, vol. 94, no. 7, pp. 849-854. https://doi.org/10.1002/bjs.5722
Lamme B, Boermeester MA, Straatsburg IH, Van Buijtenen JM, Boerma D, Offerhaus GJA et al. Early versus late surgical drainage for obstructive pancreatitis in an experimental model. British Journal of Surgery. 2007 Jul;94(7):849-854. https://doi.org/10.1002/bjs.5722
Lamme, B. ; Boermeester, M. A. ; Straatsburg, I. H. ; Van Buijtenen, J. M. ; Boerma, D. ; Offerhaus, G. J A ; Gouma, D. J. ; Van Gulik, T. M. / Early versus late surgical drainage for obstructive pancreatitis in an experimental model. In: British Journal of Surgery. 2007 ; Vol. 94, No. 7. pp. 849-854.
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