Early studies on DNA-based immunizations for measles virus

K. Yang, F. Mustafa, A. Valsamakis, J. C. Santoro, D. E. Griffin, H. L. Robinson

Research output: Contribution to journalArticlepeer-review

Abstract

DNA-mediated immunizations have been used to raise neutralizing antibodies for measles virus. Single inoculations of plasmids expressing measles hemagglutinin or fusion glycoproteins raised neutralizing antibody in BALB/c mice. Plasmids expressing the hemagglutinin glycoprotein (both normal and secreted) raised neutralizing responses that persisted for 1 year. For both forms of hemagglutinin, the effectiveness of the raised antibody (ratio of neutralizing activity to ELISA activity) was similar. High titers of neutralizing antibody were also raised by inoculation of rabbits with the hemagglutinin and fusion glycoprotein-expressing plasmids.

Original languageEnglish (US)
Pages (from-to)888-891
Number of pages4
JournalVaccine
Volume15
Issue number8
DOIs
StatePublished - Jun 1997

Keywords

  • DNA vaccines
  • Measles fusion protein
  • Measles hemagglutinin
  • Measles vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Early studies on DNA-based immunizations for measles virus'. Together they form a unique fingerprint.

Cite this