TY - JOUR
T1 - Early Stage Longitudinal Subcortical Volumetric Changes following Mild Traumatic Brain Injury
AU - Zhuo, Jiachen
AU - Jiang, Li
AU - Sours Rhodes, Chandler
AU - Roys, Steven
AU - Shanmuganathan, Karthikamanthan
AU - Chen, Hegang
AU - Prince, Jerry L.
AU - Badjatia, Neeraj
AU - Gullapalli, Rao P.
N1 - Funding Information:
This work was supported by the Department of Defense [W81XWH-08-1-0725]; National Institute of Neurological Disorders and Stroke [5R01NS10550].
Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.
PY - 2021
Y1 - 2021
N2 - Objective: To investigate early brain volumetric changes from acute to 6 months following mild traumatic brain injury (mTBI) in deep gray matter regions and their association with patient 6-month outcome. Methods: Fifty-six patients with mTBI underwent MRI and behavioral evaluation at acute (<10 days) and approximately 1 and 6 months post injury. Regional volume changes were investigated in key gray matter regions: thalamus, hippocampus, putamen, caudate, pallidum, and amygdala, and compared with volumes from 34 healthy control subjects. In patients with mTBI, we further assessed associations between longitudinal regional volume changes with patient outcome measures at 6 months including post-concussive symptoms, cognitive performance, and overall satisfaction with life. Results: Reduction in thalamic and hippocampal volumes was observed at 1 month among patients with mTBI. Such volume reduction persisted in the thalamus until 6 months. Changes in thalamic volumes also correlated with multiple symptom and functional outcome measures in patients at 6 months. Conclusion: Our results indicate that the thalamus may be differentially affected among patients with mTBI, resulting in both structural and functional deficits with subsequent post-concussive sequelae and may serve as a biomarker for the assessment of efficacy of novel therapeutic interventions.
AB - Objective: To investigate early brain volumetric changes from acute to 6 months following mild traumatic brain injury (mTBI) in deep gray matter regions and their association with patient 6-month outcome. Methods: Fifty-six patients with mTBI underwent MRI and behavioral evaluation at acute (<10 days) and approximately 1 and 6 months post injury. Regional volume changes were investigated in key gray matter regions: thalamus, hippocampus, putamen, caudate, pallidum, and amygdala, and compared with volumes from 34 healthy control subjects. In patients with mTBI, we further assessed associations between longitudinal regional volume changes with patient outcome measures at 6 months including post-concussive symptoms, cognitive performance, and overall satisfaction with life. Results: Reduction in thalamic and hippocampal volumes was observed at 1 month among patients with mTBI. Such volume reduction persisted in the thalamus until 6 months. Changes in thalamic volumes also correlated with multiple symptom and functional outcome measures in patients at 6 months. Conclusion: Our results indicate that the thalamus may be differentially affected among patients with mTBI, resulting in both structural and functional deficits with subsequent post-concussive sequelae and may serve as a biomarker for the assessment of efficacy of novel therapeutic interventions.
KW - Mild traumatic brain injury
KW - magnetic resonance imaging
KW - post concussive symptoms
KW - volumetric analysis
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U2 - 10.1080/02699052.2021.1906445
DO - 10.1080/02699052.2021.1906445
M3 - Article
C2 - 33822686
AN - SCOPUS:85103896600
VL - 35
SP - 725
EP - 733
JO - Brain Injury
JF - Brain Injury
SN - 0269-9052
IS - 6
ER -