Early Stage Longitudinal Subcortical Volumetric Changes following Mild Traumatic Brain Injury

Jiachen Zhuo, Li Jiang, Chandler Sours Rhodes, Steven Roys, Karthikamanthan Shanmuganathan, Hegang Chen, Jerry L. Prince, Neeraj Badjatia, Rao P. Gullapalli

Research output: Contribution to journalArticlepeer-review


Objective: To investigate early brain volumetric changes from acute to 6 months following mild traumatic brain injury (mTBI) in deep gray matter regions and their association with patient 6-month outcome. Methods: Fifty-six patients with mTBI underwent MRI and behavioral evaluation at acute (<10 days) and approximately 1 and 6 months post injury. Regional volume changes were investigated in key gray matter regions: thalamus, hippocampus, putamen, caudate, pallidum, and amygdala, and compared with volumes from 34 healthy control subjects. In patients with mTBI, we further assessed associations between longitudinal regional volume changes with patient outcome measures at 6 months including post-concussive symptoms, cognitive performance, and overall satisfaction with life. Results: Reduction in thalamic and hippocampal volumes was observed at 1 month among patients with mTBI. Such volume reduction persisted in the thalamus until 6 months. Changes in thalamic volumes also correlated with multiple symptom and functional outcome measures in patients at 6 months. Conclusion: Our results indicate that the thalamus may be differentially affected among patients with mTBI, resulting in both structural and functional deficits with subsequent post-concussive sequelae and may serve as a biomarker for the assessment of efficacy of novel therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)725-733
Number of pages9
JournalBrain Injury
Issue number6
StatePublished - 2021


  • Mild traumatic brain injury
  • magnetic resonance imaging
  • post concussive symptoms
  • volumetric analysis

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental and Educational Psychology
  • Clinical Neurology


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