Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1

Horacio E. Cingolani; Nestor G. Perez; Ernesto A. Aiello; Irene L. Ennis; Carolina D. Garciarena; Maria C. Villa-Abrille; Raul A. Dulce; Claudia I. Caldiz; Alejandra M. Yeves; Maria V. Correa; Mariela B. Nolly; Gladys Chiappe De Cingolani

doi:10.2741/3213

Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1

Horacio E. Cingolani, Nestor G. Perez, Ernesto A. Aiello, Irene L. Ennis, Carolina D. Garciarena, Maria C. Villa-Abrille, Raul A. Dulce, Claudia I. Caldiz, Alejandra M. Yeves, Maria V. Correa, Mariela B. Nolly, Gladys Chiappe De Cingolani

School of Medicine

Research output: Contribution to journal › Article

Abstract

The enhanced activity of the cardiac Na⁺/H⁺ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca²⁺]_i) through the Na⁺/Ca²⁺ exchanger in reverse mode (NCXrev), which triggers cardiac hypertrophy by activation of widely recognized Ca ²⁺-dependent intracellular signaling pathways.

Original language	English (US)
Pages (from-to)	7096-7114
Number of pages	19
Journal	Frontiers in Bioscience
Volume	13
Issue number	18
DOIs	https://doi.org/10.2741/3213
State	Published - May 1 2008

Keywords

Angiotensin II
Endothelin
Hypertrophy
NHE-1
Reactive Oxygen Species
Review
Slow Force Response

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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Cingolani, H. E., Perez, N. G., Aiello, E. A., Ennis, I. L., Garciarena, C. D., Villa-Abrille, M. C., Dulce, R. A., Caldiz, C. I., Yeves, A. M., Correa, M. V., Nolly, M. B., & De Cingolani, G. C. (2008). Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1. Frontiers in Bioscience, 13(18), 7096-7114. https://doi.org/10.2741/3213

Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1. / Cingolani, Horacio E.; Perez, Nestor G.; Aiello, Ernesto A.; Ennis, Irene L.; Garciarena, Carolina D.; Villa-Abrille, Maria C.; Dulce, Raul A.; Caldiz, Claudia I.; Yeves, Alejandra M.; Correa, Maria V.; Nolly, Mariela B.; De Cingolani, Gladys Chiappe.

In: Frontiers in Bioscience, Vol. 13, No. 18, 01.05.2008, p. 7096-7114.

Research output: Contribution to journal › Article

Cingolani, Horacio E. ; Perez, Nestor G. ; Aiello, Ernesto A. ; Ennis, Irene L. ; Garciarena, Carolina D. ; Villa-Abrille, Maria C. ; Dulce, Raul A. ; Caldiz, Claudia I. ; Yeves, Alejandra M. ; Correa, Maria V. ; Nolly, Mariela B. ; De Cingolani, Gladys Chiappe. / Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1. In: Frontiers in Bioscience. 2008 ; Vol. 13, No. 18. pp. 7096-7114.

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