TY - JOUR
T1 - Early side effects in treatment of childhood cancer
AU - Hughes, W. T.
N1 - Funding Information:
'Chief, Infectious Diseases Services, St. Jude Children's Research Hospital, Memphis; Professor of Pediatrics and Microbiology, University of Tennessee Center for the Health Sciences, Memphis, Tennessee Supported in part by grants CA-08480 from the National Cancer Institute, National Institutes of Health, the Elisha Sandler Fund, and by American-Lebanese Syrian Associated Chari-ties (ALSAC).
PY - 1976
Y1 - 1976
N2 - The management of childhood cancer is fraught with many paradoxes. Most of the anticancer drugs not only destroy the proliferating neoplasm but also affect normal cells. The normal tissues most affected are the bone marrow, the intestinal mucosa, and the epithelium. These tissues are most important in providing barriers to infection. Furthermore, the present approach to chemotherapy is usage of anticancer drugs at maximal tolerated doses, since the greater the concentration of drug delivered to the tumor, the greater is the chance of eradicating the malignancy. Thus, varying degrees of adverse effects must be tolerated to achieve the optimal anticancer effect. The cancer patient may need hospitalization frequently, yet the hospital environment is not the most desirable one for an immunosuppressed patient who is susceptible to nosocomial infections.
AB - The management of childhood cancer is fraught with many paradoxes. Most of the anticancer drugs not only destroy the proliferating neoplasm but also affect normal cells. The normal tissues most affected are the bone marrow, the intestinal mucosa, and the epithelium. These tissues are most important in providing barriers to infection. Furthermore, the present approach to chemotherapy is usage of anticancer drugs at maximal tolerated doses, since the greater the concentration of drug delivered to the tumor, the greater is the chance of eradicating the malignancy. Thus, varying degrees of adverse effects must be tolerated to achieve the optimal anticancer effect. The cancer patient may need hospitalization frequently, yet the hospital environment is not the most desirable one for an immunosuppressed patient who is susceptible to nosocomial infections.
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U2 - 10.1016/S0031-3955(16)33254-0
DO - 10.1016/S0031-3955(16)33254-0
M3 - Article
C2 - 815871
AN - SCOPUS:0017045779
SN - 0031-3955
VL - 23
SP - 225
EP - 232
JO - Pediatric clinics of North America
JF - Pediatric clinics of North America
IS - 1
ER -