Early severe hypoalbuminemia is an independent risk factor for intestinal failure in gastroschisis

Christopher W. Snyder, Joseph R. Biggio, Donna T. Bartle, Keith E. Georgeson, Oliver J. Muensterer

Research output: Contribution to journalArticlepeer-review


Objective: This study attempted to evaluate the association of early hypoalbuminemia with the risk of intestinal failure in gastroschisis patients. Patients and methods: Neonates with gastroschisis treated at a tertiary children's hospital over a 10-year period were initially categorized into groups based on the lowest serum albumin measurement during the first 7 days of life. Based on preliminary analysis, patients with serum albumin <1.5 g/dL were considered to have early severe hypoalbuminemia. Intestinal failure was defined as inability of the patient to wean from parenteral nutrition (PN) during the initial hospital admission, thus requiring home PN. Logistic regression modeling was performed to adjust for sex, gestational age, birth weight, and concomitant intestinal complications. Results: One hundred and thirty-five gastroschisis patients were included, of whom 21% had early severe hypoalbuminemia. Patients with early severe hypoalbuminemia had a significantly higher risk of intestinal failure compared to those with higher albumin levels (26 vs. 8%, p = 0.015). On multivariable logistic regression modeling, early severe hypoalbuminemia was strongly associated with intestinal failure (OR 6.4, 95% CI 1.8-23.3, p = 0.005). Conclusions: Early severe hypoalbuminemia appears to be an independent risk factor for long-term intestinal compromise rather than merely an indicator of overall illness. Further interventional studies are needed to determine whether clinical protocols utilizing judicious fluid administration, exogenous albumin, and early enteral feeding can improve clinical outcomes in gastroschisis.

Original languageEnglish (US)
Pages (from-to)1155-1158
Number of pages4
JournalPediatric surgery international
Issue number11
StatePublished - Nov 2011
Externally publishedYes


  • Critical care
  • Gastroschisis
  • Hypoalbuminemia
  • Intestinal motility
  • Parenteral nutrition

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery


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