Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing

H. P. Parkman, E. K. Hallinan, W. L. Hasler, G. Farrugia, K. L. Koch, L. Nguyen, W. J. Snape, T. L. Abell, R. W. Mccallum, I. Sarosiek, Pankaj Jay Pasricha, J. Clarke, L. Miriel, James A Tonascia, F. Hamilton

Research output: Contribution to journalArticle

Abstract

Background: Early satiety (ES) and postprandial fullness (PPF) are often present in gastroparesis, but the importance of these symptoms in gastroparesis has not been well-described. The aims were: (i) Characterize ES and PPF in patients with gastroparesis. (ii) Assess relationships of ES and PPF with etiology of gastroparesis, quality of life, body weight, gastric emptying, and water load testing. Methods: Gastroparetic patients filled out questionnaires assessing symptoms (PAGI-SYM) and quality of life (PAGI-QOL, SF-36v2). Patients underwent gastric emptying scintigraphy and water load testing. Key Results: 198 patients with gastroparesis (134 IG, 64 DG) were evaluated. Early satiety was severe or very severe in 50% of patients. Postprandial fullness was severe or very severe in 60% of patients. Severity scores for ES and PPF were similar between idiopathic and diabetic gastroparesis. Increasing severity of ES and PPF were associated with other gastroparesis symptoms including nausea/vomiting, satiety/early fullness, bloating, and upper abdominal pain and GERD subscores. Increasing severity of ES and PPF were associated with increasing gastroparesis severity, decreased BMI, decreased quality of life from PAGI-QOL and SF-36 physical health. Increasing severity of ES and PPF were associated with increasing gastric retention of a solid meal and decreased volume during water load test. Conclusions & Inferences: Early satiety and PPF are commonly severe symptoms in both diabetic and idiopathic gastroparesis. Early satiety and PPF severity are associated with other gastroparesis symptom severities, body weight, quality of life, gastric emptying, and water load testing. Thus, ES and PPF are important symptoms characterizing gastroparesis.

Original languageEnglish (US)
JournalNeurogastroenterology and Motility
DOIs
StateAccepted/In press - 2016

Fingerprint

Gastroparesis
Gastric Emptying
Water
Quality of Life
Body Weight
Gastroesophageal Reflux
Radionuclide Imaging
Nausea
Abdominal Pain
Vomiting
Meals
Stomach

Keywords

  • Diabetic gastroparesis
  • Early satiety
  • Gastric emptying
  • Gastroparesis

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing. / Parkman, H. P.; Hallinan, E. K.; Hasler, W. L.; Farrugia, G.; Koch, K. L.; Nguyen, L.; Snape, W. J.; Abell, T. L.; Mccallum, R. W.; Sarosiek, I.; Pasricha, Pankaj Jay; Clarke, J.; Miriel, L.; Tonascia, James A; Hamilton, F.

In: Neurogastroenterology and Motility, 2016.

Research output: Contribution to journalArticle

Parkman, HP, Hallinan, EK, Hasler, WL, Farrugia, G, Koch, KL, Nguyen, L, Snape, WJ, Abell, TL, Mccallum, RW, Sarosiek, I, Pasricha, PJ, Clarke, J, Miriel, L, Tonascia, JA & Hamilton, F 2016, 'Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing', Neurogastroenterology and Motility. https://doi.org/10.1111/nmo.12981
Parkman, H. P. ; Hallinan, E. K. ; Hasler, W. L. ; Farrugia, G. ; Koch, K. L. ; Nguyen, L. ; Snape, W. J. ; Abell, T. L. ; Mccallum, R. W. ; Sarosiek, I. ; Pasricha, Pankaj Jay ; Clarke, J. ; Miriel, L. ; Tonascia, James A ; Hamilton, F. / Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing. In: Neurogastroenterology and Motility. 2016.
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abstract = "Background: Early satiety (ES) and postprandial fullness (PPF) are often present in gastroparesis, but the importance of these symptoms in gastroparesis has not been well-described. The aims were: (i) Characterize ES and PPF in patients with gastroparesis. (ii) Assess relationships of ES and PPF with etiology of gastroparesis, quality of life, body weight, gastric emptying, and water load testing. Methods: Gastroparetic patients filled out questionnaires assessing symptoms (PAGI-SYM) and quality of life (PAGI-QOL, SF-36v2). Patients underwent gastric emptying scintigraphy and water load testing. Key Results: 198 patients with gastroparesis (134 IG, 64 DG) were evaluated. Early satiety was severe or very severe in 50{\%} of patients. Postprandial fullness was severe or very severe in 60{\%} of patients. Severity scores for ES and PPF were similar between idiopathic and diabetic gastroparesis. Increasing severity of ES and PPF were associated with other gastroparesis symptoms including nausea/vomiting, satiety/early fullness, bloating, and upper abdominal pain and GERD subscores. Increasing severity of ES and PPF were associated with increasing gastroparesis severity, decreased BMI, decreased quality of life from PAGI-QOL and SF-36 physical health. Increasing severity of ES and PPF were associated with increasing gastric retention of a solid meal and decreased volume during water load test. Conclusions & Inferences: Early satiety and PPF are commonly severe symptoms in both diabetic and idiopathic gastroparesis. Early satiety and PPF severity are associated with other gastroparesis symptom severities, body weight, quality of life, gastric emptying, and water load testing. Thus, ES and PPF are important symptoms characterizing gastroparesis.",
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T1 - Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing

AU - Parkman, H. P.

AU - Hallinan, E. K.

AU - Hasler, W. L.

AU - Farrugia, G.

AU - Koch, K. L.

AU - Nguyen, L.

AU - Snape, W. J.

AU - Abell, T. L.

AU - Mccallum, R. W.

AU - Sarosiek, I.

AU - Pasricha, Pankaj Jay

AU - Clarke, J.

AU - Miriel, L.

AU - Tonascia, James A

AU - Hamilton, F.

PY - 2016

Y1 - 2016

N2 - Background: Early satiety (ES) and postprandial fullness (PPF) are often present in gastroparesis, but the importance of these symptoms in gastroparesis has not been well-described. The aims were: (i) Characterize ES and PPF in patients with gastroparesis. (ii) Assess relationships of ES and PPF with etiology of gastroparesis, quality of life, body weight, gastric emptying, and water load testing. Methods: Gastroparetic patients filled out questionnaires assessing symptoms (PAGI-SYM) and quality of life (PAGI-QOL, SF-36v2). Patients underwent gastric emptying scintigraphy and water load testing. Key Results: 198 patients with gastroparesis (134 IG, 64 DG) were evaluated. Early satiety was severe or very severe in 50% of patients. Postprandial fullness was severe or very severe in 60% of patients. Severity scores for ES and PPF were similar between idiopathic and diabetic gastroparesis. Increasing severity of ES and PPF were associated with other gastroparesis symptoms including nausea/vomiting, satiety/early fullness, bloating, and upper abdominal pain and GERD subscores. Increasing severity of ES and PPF were associated with increasing gastroparesis severity, decreased BMI, decreased quality of life from PAGI-QOL and SF-36 physical health. Increasing severity of ES and PPF were associated with increasing gastric retention of a solid meal and decreased volume during water load test. Conclusions & Inferences: Early satiety and PPF are commonly severe symptoms in both diabetic and idiopathic gastroparesis. Early satiety and PPF severity are associated with other gastroparesis symptom severities, body weight, quality of life, gastric emptying, and water load testing. Thus, ES and PPF are important symptoms characterizing gastroparesis.

AB - Background: Early satiety (ES) and postprandial fullness (PPF) are often present in gastroparesis, but the importance of these symptoms in gastroparesis has not been well-described. The aims were: (i) Characterize ES and PPF in patients with gastroparesis. (ii) Assess relationships of ES and PPF with etiology of gastroparesis, quality of life, body weight, gastric emptying, and water load testing. Methods: Gastroparetic patients filled out questionnaires assessing symptoms (PAGI-SYM) and quality of life (PAGI-QOL, SF-36v2). Patients underwent gastric emptying scintigraphy and water load testing. Key Results: 198 patients with gastroparesis (134 IG, 64 DG) were evaluated. Early satiety was severe or very severe in 50% of patients. Postprandial fullness was severe or very severe in 60% of patients. Severity scores for ES and PPF were similar between idiopathic and diabetic gastroparesis. Increasing severity of ES and PPF were associated with other gastroparesis symptoms including nausea/vomiting, satiety/early fullness, bloating, and upper abdominal pain and GERD subscores. Increasing severity of ES and PPF were associated with increasing gastroparesis severity, decreased BMI, decreased quality of life from PAGI-QOL and SF-36 physical health. Increasing severity of ES and PPF were associated with increasing gastric retention of a solid meal and decreased volume during water load test. Conclusions & Inferences: Early satiety and PPF are commonly severe symptoms in both diabetic and idiopathic gastroparesis. Early satiety and PPF severity are associated with other gastroparesis symptom severities, body weight, quality of life, gastric emptying, and water load testing. Thus, ES and PPF are important symptoms characterizing gastroparesis.

KW - Diabetic gastroparesis

KW - Early satiety

KW - Gastric emptying

KW - Gastroparesis

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DO - 10.1111/nmo.12981

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