Early restitution of electrocorticogram predicts subsequent behavioral recovery from cardiac arrest

Andreas R. Luft, Manuel M. Buitrago, Joseph S. Paul, José Hagan, Ming chieh Ding, Nitish Thakor, Daniel F. Hanley

Research output: Contribution to journalArticle

Abstract

Previous studies have shown that parameters of EEG restitution reflect the severity of global hypoxic-ischemic brain injury. Here, the hypothesis is tested that patterns of EEG restitution during the first 4 hours predict later behavioral recovery. Time course and correlations between behavior, electrocorticogram (EcoG), and neuronal injury were investigated in a rodent model of asphyctic cardiac arrest. Forty Wistar rats were subjected to 5 minutes of asphyxia and cardiopulmonary resuscitation. Behavior was assessed by repeated scoring of neurodeficits and open field activity until euthanasia at 48 hours. Electrocorticographic bursting occurred at 13.2 ± 4 minutes after resuscitation. Bursts increased in frequency and duration until the EcoG reverted to a continuous signal. The resuscitation-continuous EcoG interval correlated with the first appearance of spontaneous movements (r = 0.80, P < 0.05). Larger intervals were associated with hyperactivity in the open field at 24 hours (r = 0.61, P < 0.05), indicating a more severe behavioral deficit. Larger intervals were also associated with worse 48-hour neurodeficit scores (P < 0.05). Neuronal damage in the hippocampus correlated with the degree of open field hyperactivity at 14 hours (P < 0.05). These findings demonstrate a close temporal and prognostic relationship between electrical and behavioral recovery after hypoxic-ischemic brain injury.

Original languageEnglish (US)
Pages (from-to)540-546
Number of pages7
JournalJournal of Clinical Neurophysiology
Volume19
Issue number6
DOIs
StatePublished - Dec 1 2002

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Keywords

  • Asphyxia
  • Electrocorticogram
  • Global hypoxic ischemic brain injury
  • Rat

ASJC Scopus subject areas

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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