TY - JOUR
T1 - Early Response to Intravitreal Dexamethasone Implant Therapy in Diabetic Macular Edema May Predict Visual Outcome
AU - on behalf of the
AU - The Dex Implant Study Group
AU - The Dex Implant Study Group
AU - Al-khersan, Hasenin
AU - Hariprasad, Seenu M.
AU - Chhablani, Jay
AU - Al-khersan, Hasenin
AU - Hariprasad, Seenu M.
AU - Chhablani, Jay K.
AU - Agarwal, Kanika
AU - Ansari, Waseem
AU - Agrawal, Kushal Umeshbhai
AU - Arevalo, J. Fernando
AU - Banker, Alay S.
AU - Farah, Michel Eid
AU - Goel, Neha
AU - Gupta, Vishali
AU - Jain, Nimesh Vinodkumar
AU - Lanzetta, Paolo
AU - Loewenstein, Anat
AU - Mehrotra, Navneet
AU - Modi, Aditya
AU - Nagpal, Manish
AU - Rosenblatt, Amir
AU - Sarao, Valentina
AU - Sarvaiya, Chintan
AU - Singh, Rishi P.
AU - Veritti, Daniele
AU - Yadav, Naresh Kumar
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/12
Y1 - 2017/12
N2 - Purpose To determine whether early visual acuity response to intravitreal dexamethasone implant therapy in diabetic macular edema (DME) is associated with long-term outcome. Design Retrospective case series. Methods Multicenter (8 sites) retrospective review of medical records of eyes with DME treated with 0.7 mg intravitreal dexamethasone implant and minimum 18-month follow-up. One hundred and two eyes were included. Eyes with vitreoretinal interface abnormalities or that had undergone vitrectomy were excluded. Eyes were categorized into 3 groups based on change in best-corrected visual acuity (BCVA) at 3 months (logMAR equivalence of <5-letter, 5-9-letter, or ≥10-letter gain). Visual acuity outcomes were determined for each early response group. The relationship between early (3-month) and overall change in BCVA was assessed using regression analysis. Results In the study population (102 eyes), <5-letter, 5- to 9-letter, and ≥10-letter BCVA improvements were seen in 44.1%, 18.6%, and 37.3% of eyes, respectively, at 3 months. Among suboptimal (<5-letter) responders at 3 months, 6.7% showed ≥10-letter gains at study conclusion compared to 29% in the robust (≥10-letter) early response group (P =.009). Change in BCVA at 3 months showed significant positive correlation with overall change in BCVA (coefficient = 0.44, P =.002). Conclusions A similar proportion of eyes demonstrated suboptimal (<5-letter) and robust (≥10-letter) early response to treatment at 3 months. Eyes with a robust early response demonstrated ≥10-letter long-term gain in BCVA at a significantly higher rate compared to those with poor early response. Early treatment response directly correlated with overall change in BCVA.
AB - Purpose To determine whether early visual acuity response to intravitreal dexamethasone implant therapy in diabetic macular edema (DME) is associated with long-term outcome. Design Retrospective case series. Methods Multicenter (8 sites) retrospective review of medical records of eyes with DME treated with 0.7 mg intravitreal dexamethasone implant and minimum 18-month follow-up. One hundred and two eyes were included. Eyes with vitreoretinal interface abnormalities or that had undergone vitrectomy were excluded. Eyes were categorized into 3 groups based on change in best-corrected visual acuity (BCVA) at 3 months (logMAR equivalence of <5-letter, 5-9-letter, or ≥10-letter gain). Visual acuity outcomes were determined for each early response group. The relationship between early (3-month) and overall change in BCVA was assessed using regression analysis. Results In the study population (102 eyes), <5-letter, 5- to 9-letter, and ≥10-letter BCVA improvements were seen in 44.1%, 18.6%, and 37.3% of eyes, respectively, at 3 months. Among suboptimal (<5-letter) responders at 3 months, 6.7% showed ≥10-letter gains at study conclusion compared to 29% in the robust (≥10-letter) early response group (P =.009). Change in BCVA at 3 months showed significant positive correlation with overall change in BCVA (coefficient = 0.44, P =.002). Conclusions A similar proportion of eyes demonstrated suboptimal (<5-letter) and robust (≥10-letter) early response to treatment at 3 months. Eyes with a robust early response demonstrated ≥10-letter long-term gain in BCVA at a significantly higher rate compared to those with poor early response. Early treatment response directly correlated with overall change in BCVA.
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U2 - 10.1016/j.ajo.2017.10.004
DO - 10.1016/j.ajo.2017.10.004
M3 - Article
C2 - 29032109
AN - SCOPUS:85034950732
SN - 0002-9394
VL - 184
SP - 121
EP - 128
JO - American journal of ophthalmology
JF - American journal of ophthalmology
ER -