Early predictors of refractory status epilepticus: An international two-center study

R. Sutter, Peter W Kaplan, S. Marsch, E. M. Hammel, S. Rüegg, Wendy C Ziai

Research output: Contribution to journalArticle


Background and purpose: Status epilepticus (SE) refractory to first- and second-line antiepileptic drugs carries high mortality. Little is known on early prediction of refractory SE (RSE) - an essential tool for planning appropriate therapy. Our aim was to identify and validate independent early RSE predictors in adults. Methods: Clinical and laboratory data on consecutive intensive care unit patients with SE from two academic care centers (a derivation data set from a Swiss center and a validation data set from a US center) were assessed. Multivariable analysis was performed with the derivation set to identify RSE predictors at SE onset. Their external validity was evaluated with an independent validation set. Measures of calibration and discrimination were assessed. Results: In all, 302 patients were analyzed (138 with and 164 without RSE), 171 in the derivation data set and 131 in the validation data set. Acute SE etiology, coma/stupor and serum albumin

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalEuropean Journal of Neurology
Issue number1
Publication statusPublished - Jan 1 2015



  • Epilepsy
  • Neurocritical care
  • Outcome
  • Refractory status epilepticus
  • Risk stratification

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this