Early postoperative cognitive dysfunction and blood pressure during coronary artery bypass graft operation

Rebecca F. Gottesman, Argye E. Hillis, Maura A. Grega, Louis M. Borowicz, Ola A. Selnes, William A. Baumgartner, Guy M. McKhann

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine the relationship between change in blood pressure during coronary artery bypass graft operations and early cognitive dysfunction. Design: Cohort study. Setting: Quaternary care facility. Patients: Fifteen patients undergoing coronary artery bypass graft operations who were at high risk for postoperative stroke. Preoperative and intraoperative mean arterial pressures (MAPs) were measured in all patients. Intervention: A subset of patients underwent preoperative and postoperative magnetic resonance imaging. Main Outcome Measure: Change in cognitive performance, using the Mini-Mental State Examination and other simple cognitive tests. Results: A drop in MAP (preoperatively to intraoperatively) predicted a decrease in Mini-Mental State Examination score. When change in MAP was dichotomized (after excluding an outlier), subjects with a small decrease improved on the Mini-Mental State Examination by 1 point, whereas those with a large drop in MAP worsened by 1.4 points (P=.04). Conclusion: A drop in MAP from a preoperative baseline may put patients at risk for early cognitive dysfunction after a coronary artery bypass graft operation.

Original languageEnglish (US)
Pages (from-to)1111-1114
Number of pages4
JournalArchives of neurology
Volume64
Issue number8
DOIs
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Early postoperative cognitive dysfunction and blood pressure during coronary artery bypass graft operation'. Together they form a unique fingerprint.

Cite this