Early postoperative changes in regional systolic and diastolic left ventricular function after transmyocardial laser revascularization

G. Chad Hughes, Ashish S. Shah, Bangliang Yin, Ming Shu, Carolyn L. Donovan, Donald D. Glower, James E. Lowe, Kevin P. Landolfo

Research output: Contribution to journalArticle

Abstract

OBJECTIVES. The purpose of this study was to determine the short-term effects of transmyocardial laser revascularization (TMR) on regional left ventricular systolic and diastolic function, myocardial blood flow (MBF) and myocardial water content (MWC). BACKGROUND. Clinical studies of TMR have noted a significant incidence of cardiac complications in the early postoperative period. However, the early post-treatment effects of laser therapy on the myocardium and their potential contribution to postoperative cardiac morbidity are unknown. METHODS. Swine underwent holmium:yttrium-aluminum-garnet (holmium:YAG) (n = 12) or carbon dioxide (CO2) (n = 12) laser TMR. Regional systolic function for the lased and nonlased regions was quantitated using preload recruitable work area (PRWA) and regional diastolic function with the ventricular stiffness constant alpha. RESULTS. Preload recruitable work area was significantly decreased in the lased regions both 1 (59.8 ± 13.0% of baseline, p = 0.02) and 6 h (64.2 ± 9.4% of baseline, p = 0.02) after holmium: YAG TMR. This decreased PRWA was associated with a significant reduction in MBF to the lased regions (13.2% reduction at 1 h, p = 0.02; 18.4% decrease at 6 h post-TMR, p = 0.01). These changes were not seen after CO2 laser TMR. A significant increase in MWC (1.4 ± 0.3% increase with holmium:YAG, p = 0.004; 1 ± 0.2% increase with CO2, p = 0.002) and alpha (217.4 ± 44.2% of baseline 6 h post-holmium:YAG TMR, p = 0.05; 206 ± 36.7% of baseline 6 h post-CO2 TMR, p = 0.03) was seen after TMR with both lasers. CONCLUSIONS. In the early postoperative setting, impaired regional systolic function in association with regional ischemia is seen after TMR with a holmium:YAG laser. Both holmium:YAG and CO2 lasers are associated with increased MWC and impaired diastolic relaxation in the lased regions. These changes may explain the significant incidence of early postoperative cardiac morbidity. The impact of these findings on anginal relief and long-term outcome are not known. (C) 2000 by the American College of Cardiology.

Original languageEnglish (US)
Pages (from-to)1022-1030
Number of pages9
JournalJournal of the American College of Cardiology
Volume35
Issue number4
DOIs
StatePublished - Mar 15 2000
Externally publishedYes

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Transmyocardial Laser Revascularization
Left Ventricular Function
Holmium
Solid-State Lasers
Gas Lasers
Water
Lasers
Morbidity
Ventricular Function
Incidence
Laser Therapy
Postoperative Period
Carbon Dioxide
Myocardium
Swine

ASJC Scopus subject areas

  • Nursing(all)

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Early postoperative changes in regional systolic and diastolic left ventricular function after transmyocardial laser revascularization. / Hughes, G. Chad; Shah, Ashish S.; Yin, Bangliang; Shu, Ming; Donovan, Carolyn L.; Glower, Donald D.; Lowe, James E.; Landolfo, Kevin P.

In: Journal of the American College of Cardiology, Vol. 35, No. 4, 15.03.2000, p. 1022-1030.

Research output: Contribution to journalArticle

Hughes, G. Chad ; Shah, Ashish S. ; Yin, Bangliang ; Shu, Ming ; Donovan, Carolyn L. ; Glower, Donald D. ; Lowe, James E. ; Landolfo, Kevin P. / Early postoperative changes in regional systolic and diastolic left ventricular function after transmyocardial laser revascularization. In: Journal of the American College of Cardiology. 2000 ; Vol. 35, No. 4. pp. 1022-1030.
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abstract = "OBJECTIVES. The purpose of this study was to determine the short-term effects of transmyocardial laser revascularization (TMR) on regional left ventricular systolic and diastolic function, myocardial blood flow (MBF) and myocardial water content (MWC). BACKGROUND. Clinical studies of TMR have noted a significant incidence of cardiac complications in the early postoperative period. However, the early post-treatment effects of laser therapy on the myocardium and their potential contribution to postoperative cardiac morbidity are unknown. METHODS. Swine underwent holmium:yttrium-aluminum-garnet (holmium:YAG) (n = 12) or carbon dioxide (CO2) (n = 12) laser TMR. Regional systolic function for the lased and nonlased regions was quantitated using preload recruitable work area (PRWA) and regional diastolic function with the ventricular stiffness constant alpha. RESULTS. Preload recruitable work area was significantly decreased in the lased regions both 1 (59.8 ± 13.0{\%} of baseline, p = 0.02) and 6 h (64.2 ± 9.4{\%} of baseline, p = 0.02) after holmium: YAG TMR. This decreased PRWA was associated with a significant reduction in MBF to the lased regions (13.2{\%} reduction at 1 h, p = 0.02; 18.4{\%} decrease at 6 h post-TMR, p = 0.01). These changes were not seen after CO2 laser TMR. A significant increase in MWC (1.4 ± 0.3{\%} increase with holmium:YAG, p = 0.004; 1 ± 0.2{\%} increase with CO2, p = 0.002) and alpha (217.4 ± 44.2{\%} of baseline 6 h post-holmium:YAG TMR, p = 0.05; 206 ± 36.7{\%} of baseline 6 h post-CO2 TMR, p = 0.03) was seen after TMR with both lasers. CONCLUSIONS. In the early postoperative setting, impaired regional systolic function in association with regional ischemia is seen after TMR with a holmium:YAG laser. Both holmium:YAG and CO2 lasers are associated with increased MWC and impaired diastolic relaxation in the lased regions. These changes may explain the significant incidence of early postoperative cardiac morbidity. The impact of these findings on anginal relief and long-term outcome are not known. (C) 2000 by the American College of Cardiology.",
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T1 - Early postoperative changes in regional systolic and diastolic left ventricular function after transmyocardial laser revascularization

AU - Hughes, G. Chad

AU - Shah, Ashish S.

AU - Yin, Bangliang

AU - Shu, Ming

AU - Donovan, Carolyn L.

AU - Glower, Donald D.

AU - Lowe, James E.

AU - Landolfo, Kevin P.

PY - 2000/3/15

Y1 - 2000/3/15

N2 - OBJECTIVES. The purpose of this study was to determine the short-term effects of transmyocardial laser revascularization (TMR) on regional left ventricular systolic and diastolic function, myocardial blood flow (MBF) and myocardial water content (MWC). BACKGROUND. Clinical studies of TMR have noted a significant incidence of cardiac complications in the early postoperative period. However, the early post-treatment effects of laser therapy on the myocardium and their potential contribution to postoperative cardiac morbidity are unknown. METHODS. Swine underwent holmium:yttrium-aluminum-garnet (holmium:YAG) (n = 12) or carbon dioxide (CO2) (n = 12) laser TMR. Regional systolic function for the lased and nonlased regions was quantitated using preload recruitable work area (PRWA) and regional diastolic function with the ventricular stiffness constant alpha. RESULTS. Preload recruitable work area was significantly decreased in the lased regions both 1 (59.8 ± 13.0% of baseline, p = 0.02) and 6 h (64.2 ± 9.4% of baseline, p = 0.02) after holmium: YAG TMR. This decreased PRWA was associated with a significant reduction in MBF to the lased regions (13.2% reduction at 1 h, p = 0.02; 18.4% decrease at 6 h post-TMR, p = 0.01). These changes were not seen after CO2 laser TMR. A significant increase in MWC (1.4 ± 0.3% increase with holmium:YAG, p = 0.004; 1 ± 0.2% increase with CO2, p = 0.002) and alpha (217.4 ± 44.2% of baseline 6 h post-holmium:YAG TMR, p = 0.05; 206 ± 36.7% of baseline 6 h post-CO2 TMR, p = 0.03) was seen after TMR with both lasers. CONCLUSIONS. In the early postoperative setting, impaired regional systolic function in association with regional ischemia is seen after TMR with a holmium:YAG laser. Both holmium:YAG and CO2 lasers are associated with increased MWC and impaired diastolic relaxation in the lased regions. These changes may explain the significant incidence of early postoperative cardiac morbidity. The impact of these findings on anginal relief and long-term outcome are not known. (C) 2000 by the American College of Cardiology.

AB - OBJECTIVES. The purpose of this study was to determine the short-term effects of transmyocardial laser revascularization (TMR) on regional left ventricular systolic and diastolic function, myocardial blood flow (MBF) and myocardial water content (MWC). BACKGROUND. Clinical studies of TMR have noted a significant incidence of cardiac complications in the early postoperative period. However, the early post-treatment effects of laser therapy on the myocardium and their potential contribution to postoperative cardiac morbidity are unknown. METHODS. Swine underwent holmium:yttrium-aluminum-garnet (holmium:YAG) (n = 12) or carbon dioxide (CO2) (n = 12) laser TMR. Regional systolic function for the lased and nonlased regions was quantitated using preload recruitable work area (PRWA) and regional diastolic function with the ventricular stiffness constant alpha. RESULTS. Preload recruitable work area was significantly decreased in the lased regions both 1 (59.8 ± 13.0% of baseline, p = 0.02) and 6 h (64.2 ± 9.4% of baseline, p = 0.02) after holmium: YAG TMR. This decreased PRWA was associated with a significant reduction in MBF to the lased regions (13.2% reduction at 1 h, p = 0.02; 18.4% decrease at 6 h post-TMR, p = 0.01). These changes were not seen after CO2 laser TMR. A significant increase in MWC (1.4 ± 0.3% increase with holmium:YAG, p = 0.004; 1 ± 0.2% increase with CO2, p = 0.002) and alpha (217.4 ± 44.2% of baseline 6 h post-holmium:YAG TMR, p = 0.05; 206 ± 36.7% of baseline 6 h post-CO2 TMR, p = 0.03) was seen after TMR with both lasers. CONCLUSIONS. In the early postoperative setting, impaired regional systolic function in association with regional ischemia is seen after TMR with a holmium:YAG laser. Both holmium:YAG and CO2 lasers are associated with increased MWC and impaired diastolic relaxation in the lased regions. These changes may explain the significant incidence of early postoperative cardiac morbidity. The impact of these findings on anginal relief and long-term outcome are not known. (C) 2000 by the American College of Cardiology.

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