Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers

Anya N A Milne, Ralph Carvalho, Folkert M. Morsink, Alex R. Musler, Wendy W J De Leng, Ari Ristimäki, G. Johan A Offerhaus

Research output: Contribution to journalArticle

Abstract

Many studies examine the molecular genetics of gastric cancer, but few look at young patients in particular and there is no comparison of molecular expression between early-onset gastric cancer (≤45 years old) and conventional gastric cancers. Expression of cycloxygenase-2 (COX-2) is elevated in gastric adenocarcinomas compared to non-neoplastic mucosa, and in light of studies showing reduced risk of gastric cancer in nonsteroidal anti-inflammatory drug users, we have chosen to investigate the expression of COX-2 and related molecules in 113 early-onset gastric cancers and compare it with 91 conventional gastric cancers, using tissue microarrays. These markers include molecules known to be important in conventional gastric carcinogenesis, such as E-Cadherin, p53, COX-2, Trefoil Factor-1 (TFF1), β-catenin, p16 and c-myc; as well as molecules not yet described as being important in gastric cancer, such as the transcription factor c-jun, the COX-2 mRNA stabilizer HuR, and C/EBP-β, a transcription factor for COX-2. All markers showed a statistically significant difference between early-onset gastric cancers and conventional gastric cancers, using a χ2 test. In particular, early-onset gastric cancers displayed a COX-2 Low, TFF1-expressing phenotype, whereas COX-2 overexpression and loss of TFF1 was found in conventional cancers, and this difference between early-onset gastric cancers and conventional cancers remained statistically significant when adjusted for location and histology (P

Original languageEnglish (US)
Pages (from-to)564-572
Number of pages9
JournalModern Pathology
Volume19
Issue number4
DOIs
Publication statusPublished - Apr 2006
Externally publishedYes

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Keywords

  • COX-2
  • Early-onset gastric cancer
  • TFF1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Milne, A. N. A., Carvalho, R., Morsink, F. M., Musler, A. R., De Leng, W. W. J., Ristimäki, A., & Offerhaus, G. J. A. (2006). Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. Modern Pathology, 19(4), 564-572. https://doi.org/10.1038/modpathol.3800563