TY - JOUR
T1 - Early Marker for Alzheimer's Disease
T2 - Hippocampus T1rho (T 1ρ) Estimation
AU - Haris, Mohammad
AU - McArdle, Erin
AU - Fenty, Matthew
AU - Singh, Anup
AU - Davatzikos, Christos
AU - Trojanowski, John Q.
AU - Melhem, Elias R.
AU - Clark, Christopher M.
AU - Borthakur, Arijitt
PY - 2009/5
Y1 - 2009/5
N2 - Purpose: To evaluate the T1rho (T 1ρ) MRI relaxation time in hippocampus in the brain of Alzheimer's disease (AD), mild cognitive impairment (MCI), and control, and to determine whether the T 1ρ shows any significant difference between these cohorts. Materials and Methods: With informed consent, AD (n 49), MCI (n = 48), and age-matched control (n = 31) un- derwent T 1ρ MRI on a Siemens 1.5T Scanner. T 1ρ values were automatically calculated from the left and right hip- pocampus region using in-house developed software. Bon- ferroni post-hoc multiple comparisons was performed to compare the T 1ρ value among the different cohorts. Results: Significantly higher T 1ρ values were observed both in AD (P = 0.000) and MCI (P = 0.037) cohorts compared to control; also, the T 1ρ in AD was significantly high over (P = 0.032) MCI. Hippocampus T 1ρ was 13% greater in the AD patients than control, while in MCI it was 7% greater than control. Hippocampus T 1ρ in AD patients was 6% greater than MCI. Conclusion: Higher hippocampus T 1ρ values in the AD pa- tients might be associated with the increased plaques bur- den. A follow-up study would help to determine the efficacy of T 1ρ values as a predictor of developing AD in the control and MCI individuals.
AB - Purpose: To evaluate the T1rho (T 1ρ) MRI relaxation time in hippocampus in the brain of Alzheimer's disease (AD), mild cognitive impairment (MCI), and control, and to determine whether the T 1ρ shows any significant difference between these cohorts. Materials and Methods: With informed consent, AD (n 49), MCI (n = 48), and age-matched control (n = 31) un- derwent T 1ρ MRI on a Siemens 1.5T Scanner. T 1ρ values were automatically calculated from the left and right hip- pocampus region using in-house developed software. Bon- ferroni post-hoc multiple comparisons was performed to compare the T 1ρ value among the different cohorts. Results: Significantly higher T 1ρ values were observed both in AD (P = 0.000) and MCI (P = 0.037) cohorts compared to control; also, the T 1ρ in AD was significantly high over (P = 0.032) MCI. Hippocampus T 1ρ was 13% greater in the AD patients than control, while in MCI it was 7% greater than control. Hippocampus T 1ρ in AD patients was 6% greater than MCI. Conclusion: Higher hippocampus T 1ρ values in the AD pa- tients might be associated with the increased plaques bur- den. A follow-up study would help to determine the efficacy of T 1ρ values as a predictor of developing AD in the control and MCI individuals.
KW - Alzheimer's disease
KW - Hippocampus
KW - MRI
KW - T1rho
UR - http://www.scopus.com/inward/record.url?scp=66149154664&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66149154664&partnerID=8YFLogxK
U2 - 10.1002/jmri.21735
DO - 10.1002/jmri.21735
M3 - Article
C2 - 19388096
AN - SCOPUS:66149154664
SN - 1053-1807
VL - 29
SP - 1008
EP - 1012
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 5
ER -