Early Liver Transplantation in Acute Alcoholic Hepatitis

Christine E. Haugen, Andrew M. Cameron

Research output: Contribution to journalArticlepeer-review

Abstract

Alcohol-related liver disease (ALD) is currently the leading indication for liver transplantation in the United States. Among patients with ALD, those with acute alcoholic hepatitis who do not respond to medical treatment have a 6-month mortality of 70% without transplantation. Despite the high mortality, the majority of patients will not be eligible for transplant, given that most centers follow the 6-month abstinence rule. A handful of centers in Europe and the United States perform early liver transplantation (< 6 months abstinence) in these patients, as it provides a substantial survival benefit. Short-term outcomes for these recipients are favorable, and relapse rates parallel those seen in alcoholic cirrhosis transplant recipients who have completed the 6-month wait period. Moving forward, studies examining long-term outcomes and candidate selection are necessary for this growing subset of liver transplant candidates.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalSeminars in Liver Disease
Volume40
Issue number1
DOIs
StatePublished - 2020

Keywords

  • alcoholic hepatitis
  • liver disease
  • liver transplant

ASJC Scopus subject areas

  • Hepatology

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