Early klrg1+ but not cd57+cd8+ t cells in primary cytomegalovirus infection predict effector function and viral control

Aki Hoji, Iulia D. Popescu, Matthew R. Pipeling, Pali D. Shah, Spencer A. Winters, John F. McDyer

Research output: Contribution to journalArticlepeer-review

Abstract

CMV remains an important opportunistic pathogen in high-risk lung transplant recipients. We characterized the phenotype and function of CD8+ T cells from acute/primary into chronic CMV infection in 23 (donor+/recipient2; D+R2) lung transplant recipients and found rapid induction of both KLRG1+ and/or CD57+ CMV-specific CD8+ T cells with unexpected coexpression of CD27. These cells demonstrated maturation from an acute effector T cell (TAEFF) to an effector memory T cell (TEM) phenotype with progressive enrichment of KLRG1+CD57+CD27- cells into memory. CMV-specific KLRG1+ TAEFF were capable of in vitro proliferation that diminished upon acquisition of CD57, whereas only KLRG1+ expression correlated with T-bet expression and effector function. In contrast to blood TAEFF, lung mucosal TAEFF demonstrated reduced KLRG1/T-bet expression but similar CD57 levels. Additionally, increased KLRG1+TAEFF were associated with early immune viral control following primary infection. To our knowledge, our findings provide new insights into the roles of KLRG1 and CD57 expression in human T cells, forming the basis for a refined model of CD8+ T cell differentiation during CMV infection.

Original languageEnglish (US)
Pages (from-to)2063-2075
Number of pages13
JournalJournal of Immunology
Volume203
Issue number8
DOIs
StatePublished - Oct 15 2019

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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