Early in vivo experience with the pediatric Jarvik 2000 heart

Ahmet Kilic, Timothy D.C. Nolan, Tieluo Li, G. Kwame Yankey, Deyanira J. Prastein, Guangming Cheng, Robert K. Jarvik, Zhongjun J. Wu, Bartley P. Griffith

Research output: Contribution to journalArticlepeer-review

Abstract

The need for smaller, more efficient ventricular assist devices that can be used in a more chronic setting have led to exploration of mechanical circulatory support in the pediatric population. The pediatric Jarvik 2000 heart (child size), under development, was implanted in six juvenile sheep and studied for both acute fit and chronic performance evaluation. Daily hemodynamic measurements of cardiac output and pump output at varying pump speeds were taken. In addition, plasma free hemoglobin, lactic acid dehydrogenase, and platelet activation from blood samples were determined at baseline, after implantation, and twice a week thereafter. The measured flow through the outflow graft at increasing speeds from 10,000 rpm to 14,000 rpm with an increment of 1,000 rpm were 1.47 ± 0.43, 1.89 ± 0.52, 2.36 ± 0.61, 2.80 ± 0.73, and 3.11 ± 0.86 (L/min). The baseline plasma free hemoglobin was 11.95 ± 4.76 (mg/dL), with subsequent mean values being <30 mg/dL at postimplantation and weekly postimplantation measurements. Both lactic acid dehydrogenase and platelet activation showed an acute increase within the first week after implantation with subsequent return to baseline by 2 weeks after surgery. Our initial animal in vivo experience with the pediatric Jarvik 2000 heart shows that a small axial flow pump can provide partial to nearly complete circulatory support with minimal adverse effects on blood components.

Original languageEnglish (US)
Pages (from-to)374-378
Number of pages5
JournalASAIO Journal
Volume53
Issue number3
DOIs
StatePublished - May 2007
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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