Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells

Shan Shan Wang, Hai Yan Huang, Su Zhen Chen, Xi Li, Yang Liu, Wen Ting Zhang, Qi Qun Tang

Research output: Contribution to journalArticlepeer-review

Abstract

Early growth response 2 (Egr2) is a zinc-finger transcription factor that acts as an important modulator of a variety of physiological processes, such as cell differentiation, proliferation and apoptosis. Here we showed that Egr2 was downregulated by bone morphogenetic protein (BMP) signaling pathways during the commitment of C3H10T1/2 stem cells to adipocyte lineage. Overexpression of Egr2 completely prevented BMP4-induced adipocyte lineage commitment of C3H10T1/2 stem cells, while simultaneously stimulating early smooth muscle-like differentiation. We also demonstrated that Egr2-induced early smooth muscle-like differentiation is transforming growth factor β1-independent. Egr2 can activate the transcription of early smooth muscle cell specific genes smooth muscle protein 22 α and calponin 1.Together, the results indicated a novel role for Egr2 in repressing adipocyte lineage commitment and promoting early smooth muscle-like cell differentiation.

Original languageEnglish (US)
Pages (from-to)1825-1832
Number of pages8
JournalInternational Journal of Biochemistry and Cell Biology
Volume45
Issue number8
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Adipogenesis
  • C3H10T1/2
  • Egr2
  • Smooth muscle cellCommitmenta

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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