Early glandular neoplasia of the lung

William H. Westra

Research output: Contribution to journalArticle

Abstract

Although bronchogenic carcinomas progress through a very well defined sequence of metaplasia, dysplasia and carcinoma in situ, very little is known about the early progression of glandular neoplasms of the lung. In particular, the early precursor lesion from which fully malignant adenocarcinomas arise has effectively eluded recognition, at least until recently. Several lines of evidence now implicate atypical adenomatous hyperplasia (AAH) as an initial morphologic stage in multistep lung tumorigenesis. Despite its small size, AAH can be appreciated at the light microscopic level and characterized at the molecular genetic level. Indeed, the genetic characterization of AAH promises to further our understanding of lung cancer development and might facilitate the design of novel strategies for early detection of lung cancer.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalRespiratory Research
Volume1
Issue number1
DOIs
StatePublished - Nov 17 2000

Fingerprint

Hyperplasia
Lung
Lung Neoplasms
Neoplasms
Glandular and Epithelial Neoplasms
Bronchogenic Carcinoma
Carcinoma in Situ
Metaplasia
Early Detection of Cancer
Molecular Biology
Carcinogenesis
Adenocarcinoma
Light

Keywords

  • Adenocarcinoma
  • Atypical adenomatous hyperplasia
  • Atypical alveolar hyperplasia
  • K-ras
  • Loss of heterozygosity
  • Lung cancer
  • p53
  • Telomerase

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Early glandular neoplasia of the lung. / Westra, William H.

In: Respiratory Research, Vol. 1, No. 1, 17.11.2000, p. 163-169.

Research output: Contribution to journalArticle

Westra, William H. / Early glandular neoplasia of the lung. In: Respiratory Research. 2000 ; Vol. 1, No. 1. pp. 163-169.
@article{f38641fc34134115b830baf699baf5d9,
title = "Early glandular neoplasia of the lung",
abstract = "Although bronchogenic carcinomas progress through a very well defined sequence of metaplasia, dysplasia and carcinoma in situ, very little is known about the early progression of glandular neoplasms of the lung. In particular, the early precursor lesion from which fully malignant adenocarcinomas arise has effectively eluded recognition, at least until recently. Several lines of evidence now implicate atypical adenomatous hyperplasia (AAH) as an initial morphologic stage in multistep lung tumorigenesis. Despite its small size, AAH can be appreciated at the light microscopic level and characterized at the molecular genetic level. Indeed, the genetic characterization of AAH promises to further our understanding of lung cancer development and might facilitate the design of novel strategies for early detection of lung cancer.",
keywords = "Adenocarcinoma, Atypical adenomatous hyperplasia, Atypical alveolar hyperplasia, K-ras, Loss of heterozygosity, Lung cancer, p53, Telomerase",
author = "Westra, {William H.}",
year = "2000",
month = "11",
day = "17",
doi = "10.1186/rr28",
language = "English (US)",
volume = "1",
pages = "163--169",
journal = "Respiratory Research",
issn = "1465-9921",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Early glandular neoplasia of the lung

AU - Westra, William H.

PY - 2000/11/17

Y1 - 2000/11/17

N2 - Although bronchogenic carcinomas progress through a very well defined sequence of metaplasia, dysplasia and carcinoma in situ, very little is known about the early progression of glandular neoplasms of the lung. In particular, the early precursor lesion from which fully malignant adenocarcinomas arise has effectively eluded recognition, at least until recently. Several lines of evidence now implicate atypical adenomatous hyperplasia (AAH) as an initial morphologic stage in multistep lung tumorigenesis. Despite its small size, AAH can be appreciated at the light microscopic level and characterized at the molecular genetic level. Indeed, the genetic characterization of AAH promises to further our understanding of lung cancer development and might facilitate the design of novel strategies for early detection of lung cancer.

AB - Although bronchogenic carcinomas progress through a very well defined sequence of metaplasia, dysplasia and carcinoma in situ, very little is known about the early progression of glandular neoplasms of the lung. In particular, the early precursor lesion from which fully malignant adenocarcinomas arise has effectively eluded recognition, at least until recently. Several lines of evidence now implicate atypical adenomatous hyperplasia (AAH) as an initial morphologic stage in multistep lung tumorigenesis. Despite its small size, AAH can be appreciated at the light microscopic level and characterized at the molecular genetic level. Indeed, the genetic characterization of AAH promises to further our understanding of lung cancer development and might facilitate the design of novel strategies for early detection of lung cancer.

KW - Adenocarcinoma

KW - Atypical adenomatous hyperplasia

KW - Atypical alveolar hyperplasia

KW - K-ras

KW - Loss of heterozygosity

KW - Lung cancer

KW - p53

KW - Telomerase

UR - http://www.scopus.com/inward/record.url?scp=0037890342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037890342&partnerID=8YFLogxK

U2 - 10.1186/rr28

DO - 10.1186/rr28

M3 - Article

VL - 1

SP - 163

EP - 169

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

IS - 1

ER -