Early events in the neoplastic transformation of respiratory epithelium.

M. J. Birrer, R. Alani, F. Cuttitta, L. H. Preis, A. L. Sabich, D. A. Sanders, J. M. Siegfried, E. Szabo, P. H. Brown

Research output: Contribution to journalArticle

Abstract

The complex process of epithelial carcinogenesis is composed of discrete biologic events including the early activation events of "initiation" and "promotion." For lung cancer, these events are only now being elucidated. Despite the identification of possible target genes and their mutations, the "initiation" events for lung cancer remain poorly understood. The identification of these "initiation" events is a crucial step toward the development of practical molecular markers for early detection of this disease. The reversible process of tumor promotion remains somewhat enigmatic but is a promising target for chemoprevention. A wide range of substances, including asbestos and various substances in cigarette smoke, behave as tumor promoters for lung cancer. They appear to promote tumor formation by inducing cellular proliferation mediated in part by growth factors. The intracellular signals these factors provide are ultimately translated into cellular growth via steps involving nuclear transcription factors. Early response genes such as the jun and fos gene family members encode such nuclear transcription factors which are expressed in lung cancer cells and primary bronchial epithelial cells. The expression of these transcription factors is highly responsive to stimulation by growth factors including serum, transforming growth factor, and gastrin-releasing peptide. A more thorough understanding of this process will allow the development of molecular and/or pharmacologic antagonists that can interfere with the biologic process of tumor promotion and therefore function as chemoprevention agents.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalJournal of the National Cancer Institute. Monographs
Issue number13
StatePublished - 1992
Externally publishedYes

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Respiratory Mucosa
Lung Neoplasms
Transcription Factors
Chemoprevention
Intercellular Signaling Peptides and Proteins
jun Genes
Gastrin-Releasing Peptide
fos Genes
Neoplasms
Asbestos
Transforming Growth Factors
Smoke
Tobacco Products
Carcinogens
Genes
Early Diagnosis
Carcinogenesis
Epithelial Cells
Cell Proliferation
Mutation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Birrer, M. J., Alani, R., Cuttitta, F., Preis, L. H., Sabich, A. L., Sanders, D. A., ... Brown, P. H. (1992). Early events in the neoplastic transformation of respiratory epithelium. Journal of the National Cancer Institute. Monographs, (13), 31-37.

Early events in the neoplastic transformation of respiratory epithelium. / Birrer, M. J.; Alani, R.; Cuttitta, F.; Preis, L. H.; Sabich, A. L.; Sanders, D. A.; Siegfried, J. M.; Szabo, E.; Brown, P. H.

In: Journal of the National Cancer Institute. Monographs, No. 13, 1992, p. 31-37.

Research output: Contribution to journalArticle

Birrer, MJ, Alani, R, Cuttitta, F, Preis, LH, Sabich, AL, Sanders, DA, Siegfried, JM, Szabo, E & Brown, PH 1992, 'Early events in the neoplastic transformation of respiratory epithelium.', Journal of the National Cancer Institute. Monographs, no. 13, pp. 31-37.
Birrer MJ, Alani R, Cuttitta F, Preis LH, Sabich AL, Sanders DA et al. Early events in the neoplastic transformation of respiratory epithelium. Journal of the National Cancer Institute. Monographs. 1992;(13):31-37.
Birrer, M. J. ; Alani, R. ; Cuttitta, F. ; Preis, L. H. ; Sabich, A. L. ; Sanders, D. A. ; Siegfried, J. M. ; Szabo, E. ; Brown, P. H. / Early events in the neoplastic transformation of respiratory epithelium. In: Journal of the National Cancer Institute. Monographs. 1992 ; No. 13. pp. 31-37.
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